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© The Rockefeller University Press, 0021-9525/2003/12/928 $8.00
The Journal of Cell Biology, Volume 163, Number 5, 928-929

Civil war in the immune system

Arthritis (left) gets worse if the immune system is prevented from making antibodies to its own TNF- (right). Karin/Immunity

Autoimmunity seems like a model for the immune system gone awry, but things could be a lot worse, say Gizi Wildbaum, Menahem Nahir, and Nathan Karin (Technion, Haifa, Israel). They find that the immune system responds to autoimmunity, and thus keeps itself in check, by making antibodies to its own pro-inflammatory mediators.

Clues to this self-regulatory behavior emerged from earlier immunization studies. The group succeeded in combating autoimmune diseases by injecting adjuvant plus DNA vaccines encoding pro-inflammatory mediators. Antibodies against the vaccine-encoded mediators apparently dampened both inflammation and disease. But this antibody response looked less like a de novo response and more like the amplification of an existing response.

Sure enough, when the Israeli group looked in models of autoimmunity, they found antibody responses against common pro-inflammatory mediators such as TNF-. The anti–TNF- response could be prevented by inducing neonatal tolerance to TNF-; this resulted in a much more serious disease after subsequent induction of autoimmunity mimicking rheumatoid arthritis.

The natural antibody response was directed at pro-inflammatory rather than regulatory mediators, and was seen only during autoimmune rather than local inflammatory reactions. This specificity remains a mystery. "The next question is to find the difference between an immune response and an autoimmune response," says Karin. "Nobody has really found a difference." One possibility is that the immune system somehow reacts to any self protein that rises far above its normal level. Or there may be earlier controls on the production or regulation of the cells that make the antimediator antibodies. "We're entering an empty field here," says Karin. "It's not an easy question to answer."

Reference:

Wildbaum, G., et al. 2003. Immunity. 19:679–688.[CrossRef][Medline]

William A. Wells

wellsw{at}rockefeller.edu

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This Article Full Text (PDF, 425K) PPT slides of all figures Alert me when this article is cited Services Email this article Similar articles in this journal Alert me to new content in the JCB Download to citation manager Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Wells, W. A. Search for Related Content PubMed Articles by Wells, W. A. Social Bookmarking                            What's this?