Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents

This Article Full Text (PDF, 687K) Alert me when this article is cited Services Email this article Similar articles in this journal Alert me to new content in the JCB Download to citation manager Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by LeBrasseur, N. Search for Related Content PubMed Articles by LeBrasseur, N. Social Bookmarking                            What's this?

APC proteolysis not overdone

Smart antigen-presenting cells (APCs) use proteolysis with restraint, according to Lélia Delamarre, Ira Mellman, Sergio Trombetta, and colleagues (Yale University, New Haven, CT). Although perhaps contrary to prevailing assumptions, this less-is-more approach may prevent excessive or premature peptide processing.

"We've been led to believe that, since so many different antigens have to be made, APCs need a large, diverse set of [protease] activities," says Mellman. But dendritic cells (DCs) and B cells are no more endowed with lysosomal proteases than is the average fibroblast, based on the new results. Of the APCs tested, only macrophages were particularly protease packed.

Reference:

Delamarre, L., et al. 2005. Science. 307:1630–1634.[Abstract/Free Full Text]

Nicole LeBrasseur

lebrasn{at}rockefeller.edu

CiteULike    Complore    Connotea    Del.icio.us    Digg    Facebook    Reddit    Technorati    Twitter    What's this?

This Article Full Text (PDF, 687K) Alert me when this article is cited Services Email this article Similar articles in this journal Alert me to new content in the JCB Download to citation manager Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by LeBrasseur, N. Search for Related Content PubMed Articles by LeBrasseur, N. Social Bookmarking                            What's this?