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Collective guidance wisdom

A border cell cluster (red, blue) follows the leading cell (green) containing the most guidance signal. RØRTH

Traditionally, cell migration studies focus on the responses of a single cell to guidance signals, but migrations during development and metastasis involve traveling clumps of cells. Pernille Rørth and colleagues (EMBL, Heidelberg, Germany) now show that a collective consciousness can direct the migration of cell clusters.

The team tracked two distinct migration phases—a quick start and a later, slower phase—by the border cell cluster in developing fly egg chambers. They found that the phases required different growth factor–induced signaling pathways; only the latter was controlled by MAPK and PLC.

While early signals were restricted to the front of the cluster's leader, the later MAPK signal was uniform throughout leading cells. How this signal could direct movement puzzled the group until they considered that the cluster might be guided as a unit. Movies revealed that, in the late phase, the cluster slowed to a tumbling, shuffling motion in which the leading cell or two—ones with the most MAPK signaling—often changed identity.

The shuffling means that cells are constantly in competition for who is "seeing" growth factor best at any given moment by being closest to the ligand source and sensing it best. This group mentality, which can assess a larger environment than individual cells, may boost migration precision.

Reference:

Bianco, A., et al. 2007. Nature. 448:362–365.[CrossRef][Medline]

Kendall Powell

kendall2{at}nasw.org

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This Article Full Text (PDF, 776K) PPT slides of all figures Alert me when this article is cited Services Email this article Similar articles in this journal Alert me to new content in the JCB Download to citation manager Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Powell, K. Search for Related Content PubMed Articles by Powell, K. Social Bookmarking                            What's this?