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Cholesterol and Alzheimer's

Alzheimer's disease (AD) presents in early- and late-onset forms that share the same neuronal pathology but have different genetic causes. A new study by Qiang Liu, Guojun Bu (Washington University, St. Louis, MO), and colleagues now suggests that both AD forms are linked to a cholesterol pathway.

Cholesterol was already linked to late-onset AD. The best-known risk factor for this disease is a specific form of apolipoprotein E (apoE), which delivers lipids such as cholesterol to neurons. But early-onset AD stems from mutations in genes encoding amyloid precursor protein (APP) or its cleaving enzymes, which result in the accumulation of disease-associated Aß amyloids. How these disparate pathways both lead to AD was not known.

In addition to Aß, APP cleavage also produces the APP intracellular domain (AICD) peptide. Liu et al. now show that AICD blocks the apoE pathway, thereby lowering cholesterol levels in the brain. AICD blocked the lipid's import into neurons by reducing the expression of the apoE receptor, LRP1.

In AD, APP processing gone awry might cause AICD to accumulate, thus depriving neurons of cholesterol. Both early and late forms of AD may therefore stem at least in part from faulty, cholesterol-deprived neurons.

"We now have a better idea of APP's function in the brain," says Bu. "It could be linked to disease through both Aß-dependent and -independent mechanisms."

Reference:

Liu, Q., et al. 2007. Neuron. 56:66–78.[CrossRef][Medline]

Caitlin Sedwick

csedwick{at}gmail.com

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This Article Full Text (PDF, 1065K) Alert me when this article is cited Services Email this article Similar articles in this journal Alert me to new content in the JCB Download to citation manager Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Sedwick, C. Search for Related Content PubMed Articles by Sedwick, C. Social Bookmarking                            What's this?