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Index of Online Supplemental Material for
J. Cell Biol. 10.1083/jcb.200208179
Srinivasan et al.
• Figure S1 Rac but not Cdc42 is necessary for PI(3,4,5)P3 accumulation.
• Figure S2 Inhibition of Rac activity blocks polarity, whereas inhibition of Cdc42 activity prevents the consolidation of one leading edge.
• Figure S3 Inhibition of Cdc42 activity leads to a range of phenotypes consistent with an inability to stabilize one leading edge.
• Video 1 (136 K) Polarization after exposure to a uniform concentration of fMLP.
• Video 2 (856 K) Effect of Cdc42N17 on response to a uniform concentration of fMLP.
• Video 3 (128 K) Polarization and migration toward fMLP in a micropipette.
• Video 4 (204 K) Inhibition of Cdc42 prevents formation of a persistent pseudopod oriented toward a micropipette source of fMLP.
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