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Index of Online Supplemental Material for
J. Cell Biol. 10.1083/jcb.200209006
Wolf et al.
• Video 1 (10 MB) Fibroblast-like, mesenchymal migration of HT1080/MT1-MMP cells through 3D collagen matrix. (B) Blocking of ß1 integrins (mAb 4B4).
• Video 2 (7.1 MB) Proteolytic migration of HT-1080/M1 cells (time-lapse confocal microscopy).
• Video 3 (9.5 MB) Constitutive spindle-shaped, fibroblast-like morphodynamics and migration convert to amoeboid migration in the presence of protease inhibitor cocktail in HT-1080/MT1 cells (simultaneous time-lapse video microscopy).
• Video 4 (3.9 MB) Induced amoeboid migration of HT-1080/MT1 cells in the presence of protease inhibitor cocktail.
• Video 5 (13.9 MB) The conversion of constitutive mesenchymal migration towards nonproteolytic amoeboid movement of MDA-MB-231 cells in the presence of protease inhibitor cocktail
• Video 6 (6.8 MB) Protease-independent crawling lacks structural matrix remodeling. Fiber bundling at leading and trailing edges is reduced.
• Video 7 (2.4 MB) Constriction rings: nonproteolytic bypassing of matrix constraints by shape change.
• Video 8 (7 MB) Intravital multiphoton microscopy (z-scan): mesenchymal and induced amoeboid morphology in HT-1080/MT1 cells after injection into the mouse dermis.
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