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Index of Online Supplemental Material for
J. Cell Biol. 10.1083/jcb.200603176
Saunders et al.
• Figure S1 EC invasion of 3D collagen matrices is markedly inhibited by ECs expressing TIMP-3 but not by ECs expressing TIMP-1.
• Figure S2 TIMP-3 stabilizes ECs undergoing EC tubular network formation or regression, whereas anti-α2-integrin-blocking antibodies cause the rapid collapse of EC tubular networks.
• Figure S3 TIMP-3 blocks further lumen development and network remodeling when added to preexisting EC tubular networks without causing the collapse of these structures.
• Figure S4 Suppression of membrane-associated metalloproteinases via siRNAs in ECs indicates a critical role for MT1-MMP in S1P-mediated invasion of 3D collagen matrices.
• Figure S5 Suppression of membrane-associated metalloproteinases via siRNAs in ECs indicates a critical role for MT1-MMP, MT2-MMP, and ADAM-15 in SDF-1α-mediated invasion of 3D collagen matrices.
• Video 1 Time-lapse video of control EC tube morphogenesis in 3D collagen matrices.
• Video 2 Time-lapse video of normal EC tube morphogenesis in the presence of TIMP-1 in 3D collagen matrices.
• Video 3 Time-lapse video of the blockade of EC tube morphogenesis by TIMP-2 in 3D collagen matrices.
• Video 4 Time-lapse video of the blockade of EC tube morphogenesis by TIMP-3 in 3D collagen matrices.
• Video 5 Time-lapse video of the blockade of EC tube morphogenesis by the MMP inhibitor GM6001 in 3D collagen matrices.
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