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Index of Online Supplemental Material for
J. Cell Biol. 10.1083/jcb.200609061
Gauthier et al.
• Figure S1 Vesicles containing VacA exhibit F-actin structures and move rapidly in the cytosol.
• Figure S2 Treatment of cells by CD inhibits the motility of VacA-containing vesicles.
• Figure S3 Quantification of F-actin structures on early and late endosomes and for each CD2AP construct.
• Figure S4 CD2AP knockdown by siRNA leads to a loss of F-actin structures associated with EE and to an increase of stress fibers.
• Figure S5 The Cy5-VacA toxin has identical intracellular trafficking and vacuolating activity to the native toxin.
• Video 1 360° rotation of a 3D reconstructed HeLa cell presented in Fig. 1
• Video 2 360° rotation of a 3D reconstructed HeLa cell presented in Fig. 1
• Video 3 360° rotation of a 3D reconstructed HeLa cell presented in Fig. 1
• Video 4 360° rotation of a 3D reconstructed part of a HeLa cell processed as described in Fig. 2
• Video 5 Vesicles containing VacA exhibit F-actin structures and move rapidly in the cytosol.
• Video 6 Endosomes containing VacA exhibit F actin structures and move rapidly in the cytosol.
• Video 7 360° rotation of a 3D reconstructed HeLa cell processed as described in Fig. 3
• Video 8 CD2AP is associated with dynamic F-actin structures.
• Video 9 360° rotation of a 3D reconstructed HeLa cell processed as described in Fig. 5
• Video 10 Expression of the first two SH3 domains of CD2AP inhibits the vacuolation of LEs induced by VacA.
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