|
|
|
|
|
|
|
||
| ||||||||||||||||||||||||||
Index of Online Supplemental Material for
J. Cell Biol. 10.1083/jcb.200703044
Xiong et al.
• Figure S1 The lack of IGF-1R impairs p53 and p21 induction in response to doxorubicin and Taxol treatment and blocks etoposide-induced G1 cell cycle arrest, whereas it sensitizes MEFs to doxorubicin and Taxol-induced apoptosis
• Figure S2 IGF-IR inhibition attenuates etoposide-induced p53 induction and apoptosis in tumor cells.
• Figure S3 IGF-IR inhibition increases p53 protein stability in tumor cells.
• Figure S4 IGF-IR inhibition decreases p53 translation.
• Figure S5 IGF-1R inhibition impairs p53 and mdm2 mRNA translation through an ERK- and GSK-3β- and PI-3K--Akt--mTOR--independent mechanism.
| ||||||||||||||||||||||||||
|
|
