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Index of Online Supplemental Material for
J. Cell Biol. 10.1083/jcb.200706099
Pearson et al.
• Figure S1 MEK1/2 is necessary for induction of noninvasive motility.
• Figure S2 Costaining of acini with two different α – phospho-MLC2S19 antibodies.
• Figure S3 MLCK and ROCK1/2 are necessary for induction of noninvasive motility.
• Video 1 Cells in control acini are not motile.
• Video 2 Noninvasive motility promotes the disruption of epithelial architecture.
• Video 3 Cells can enter and exit the lumen but do not become invasive.
• Video 4 Cells can move at different speeds and in different directions.
• Video 5 A three-dimensional reconstruction of a control acinus shows no cell movement.
• Video 6 A three-dimensional reconstruction of a Raf-ER–induced acinus shows extensive cell movement.
• Video 7 Neither cells on the surface nor within the lumen of control acini are motile.
• Video 8 Cells both on the surface and within the lumen of Raf-ER–induced acini are motile.
• Video 9 Uninduced GFP–Raf-ER–MCF-10A cells are not motile in monolayer culture.
• Video 10 GFP–Raf-ERinduced MCF-10A cells are motile in monolayer culture.
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