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Index of Online Supplemental Material for
J. Cell Biol. 10.1083/jcb.200804140
Caswell et al.
• Figure S1 Validation of shRNA hairpin vectors.
• Figure S2 Rab11 is required for α5β1 recycling in A2780 cells.
• Figure S3 Time course of association of α5β1 with RCP after addition of cilengitide.
• Figure S4 Inhibition of αvβ3 promotes the recruitment of α5β1 and RCP to actin-rich protrusions.
• Figure S5 Dominant-negative FIP2 and Rip11 do not inhibit A2780 cell migration into FN-containing matrigel.
• Video 1 Cilengitide promotes a rapid/random mode of cell migration that is opposed by expression of dominant-negative RCP.
• Video 2 Cilengitide promotes a rapid/random mode of cell migration that is opposed by expression of dominant-negative RCP.
• Video 3 Cilengitide promotes a rapid/random mode of cell migration that is opposed by expression of dominant-negative RCP.
• Video 4 Cilengitide and osteopontin induce the formation of highly dynamic actin-rich protrusions at the cell front.
• Video 5 Cilengitide and osteopontin induce the formation of highly dynamic actin-rich protrusions at the cell front.
• Video 6 Cilengitide and osteopontin induce the formation of highly dynamic actin-rich protrusions at the cell front.
• Video 7 ilengitide promotes a pseudopodial mode of cell migration on cell-derived matrix that is opposed by expression of RCP621E.
• Video 8 Cilengitide promotes a pseudopodial mode of cell migration on cell-derived matrix that is opposed by expression of RCP621E.
• Video 9 Cilengitide promotes a pseudopodial mode of cell migration on cell-derived matrix that is opposed by expression of RCP621E.
• Video 10 GFP-RCP is localized to the tip of the extending pseudopod as cells migrate on a 3D matrix.
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