biosights: July 14, 2009
Microtubules gain stability by losing a tyrosine
The Rockefeller University Press
biosights{at}rockefeller.edu
The C-terminus of α-tubulin was thought to lose a tyrosine residue in response to microtubule stabilization, but new research shows that the opposite is true: tyrosine removal causes microtubules to stabilize by reducing the efficiency of depolymerizing motor proteins. This biosights episode presents a paper by Peris et al. in the Journal of Cell Biology, and includes interviews with authors Leticia Peris and Annie Andrieux. Produced by Justin Paul and Ben Short.
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