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Published online
doi:10.1083/jcb.200907119
The Journal of Cell Biology, Vol. 186, No. 4, 457-459
The Rockefeller University Press, 0021-9525 $30.00
© Nichols
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Endocytosis of lipid-anchored proteins: excluding GEECs from the crowd



Ben Nichols

Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, England, UK

Correspondence to Ben Nichols: ben{at}mrc-lmb.cam.ac.uk

Endocytosis of glycosylphosphatidylinositol (GPI)-linked proteins via a specific pathway into GPI-enriched early endosomal compartments (GEECs) has been proposed. How sorting into this pathway may take place is unclear. In this issue, Bhagatji et al. (2009. J. Cell Biol. doi:10.1083/jcb.200903102) provide an original mechanism for the sorting of lipid-anchored proteins that involves exclusion of bulky extracellular domains from clathrin-coated pits.

© 2009 Nichols
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Related Article

Steric and not structure-specific factors dictate the endocytic mechanism of glycosylphosphatidylinositol-anchored proteins
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J. Cell Biol. 2009 186: 615-628. [Abstract] [Full Text] [PDF]





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