Article Figures & Data
Figures
- Figure 1
InterPro alignment of VWF to the protein that it most resembles in the Drosophila genome. Representation of domains of the human VWF protein and the most similar predicted Drosophila protein (not drawn to scale). The Drosophila ORF with the best sequence similarity to human VWF (bottom) has several VWF-C domains (black), a VWF-D domain (gray), and a very low E value when aligned to human VWF (top). However, it has no VWF-A domains (white), which bind GPIIb, collagen and heparin, and are crucial for the function of the human protein. Thus the Drosophila predicted protein is unlikely to represent a true homologue of human VWF.
- Figure 2
Alignment of the human and Drosophila Menin proteins. The human (bottom line) and Drosophila (top line) Menin proteins were aligned using the MacVector 6.5 ClustalW program with the BLOSUM 30 matrix and an open gap penalty of 10. The fly protein is 34% identical and 47% similar to the human protein over its entire length.
- Figure 3
Alignment of the human and Drosophila Peutz-Jeghers STK11 kinases. The human (bottom line) and Drosophila (top line) Peutz-Jeghers disease STK11 kinases were aligned using the MacVector 6.5 ClustalW program with the BLOSUM 30 matrix and an open gap penalty of 10. The fly protein is 43% identical and 56% similar to the human protein over its entire length.
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February 4, 2019
Volume 218, No. 2