September 2011 | Volume 194, No. 5
News
In This Issue
In Focus
Budding yeast star in their own biofilmStudy describes the multicellular, differentiated structures formed by wild strains of S. cerevisiae.
People & Ideas
Ruth Lehmann: Germ cells do things differentlyLehmann studies the developmental program that sets the germ line apart from somatic cells.
Editorial
Reviews
Comment
Review
Research Articles
Report
Flo11p, drug efflux pumps, and the extracellular matrix cooperate to form biofilm yeast coloniesBiofilm yeast colonies are complex structures that form through cooperative action of constituent cells and provide a protective environment for cell growth.
Articles
The nucleolus directly regulates p53 export and degradationNucleoli directly regulate p53 export and degradation rather than simply sequestering p53 regulatory factors.
Cdk1 uncouples CtIP-dependent resection and Rad51 filament formation during M-phase double-strand break repairM-phase DNA double-strand break repair differs from S-phase repair caused by the action of Cdk1, which prevents RPA-bound single-stranded DNA from activating classical DNA repair pathways.
Epigenetic displacement of HP1 from heterochromatin by HIV-1 Vpr causes premature sister chromatid separationThe HIV-1 protein Vpr disrupts higher-order chromatin structure by altering histone modification and displacing important heterochromatin proteins, resulting in chromatid cohesion defects.
Mindbomb 1, an E3 ubiquitin ligase, forms a complex with RYK to activate Wnt/β-catenin signalingMIB1 ubiquitin ligase–mediated regulation of internalization of the Wnt receptor RYK is necessary for response to Wnt3a ligand in cell culture and C. elegans.
DLK induces developmental neuronal degeneration via selective regulation of proapoptotic JNK activityDLK is part of a specialized JNK signaling complex in axons that promotes apoptosis via c-Jun but axon degeneration via distinct JNK substrates.
Coatomer and dimeric ADP ribosylation factor 1 promote distinct steps in membrane scissionDuring membrane budding, coatomer drives initial curvature of the bud, whereas dimeric Arf1 is necessary for membrane scission.
GCC185 plays independent roles in Golgi structure maintenance and AP-1–mediated vesicle tetheringTwo distinct domains of GCC185 function in maintaining Golgi structure or in binding to AP-1 to tether retrograde transport vesicles en route to the Golgi.
Tools
Comparative RNAi screening identifies a conserved core metazoan actinome by phenotypeRNAi screens in Drosophila and human cells for novel actin regulators revealed conserved roles for proteins involved in nuclear actin export, RNA splicing, and ubiquitination.
