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February 2013 | Volume 200, No. 4

News

  • In This Issue

    • Telocentrosomes organize telomere gathering
      Telocentrosomes organize telomere gathering
      Mitch Leslie
    • SecYEG gets grabby with new proteins
      SecYEG gets grabby with new proteins
      Mitch Leslie
    • Condensin II helps sisters find their identity
      Condensin II helps sisters find their identity
      Mitch Leslie
  • In Focus

    • Endocytosis puts exocytosis in pole position
      Endocytosis puts exocytosis in pole position

      Researchers find that endocytosis confines exocytosis to narrow zone during cell polarization.

      Mitch Leslie
  • People & Ideas

    • Stephen Doxsey: At the (peri)center of things
      Stephen Doxsey: At the (peri)center of things

      Doxsey studies how centrosomes and pericentriolar material affect cell function.

      Caitlin Sedwick

Reviews

  • Comment

    • Exosomes: Looking back three decades and into the future
      Exosomes: Looking back three decades and into the future
      Clifford V. Harding, John E. Heuser, Philip D. Stahl
  • Review

    • Extracellular vesicles: Exosomes, microvesicles, and friends
      Extracellular vesicles: Exosomes, microvesicles, and friends
      Graça Raposo, Willem Stoorvogel

Research Articles

  • Reports

    • Microtubule-organizing center formation at telomeres induces meiotic telomere clustering
      Microtubule-organizing center formation at telomeres induces meiotic telomere clustering

      Telomere-localized SUN and KASH proteins induce formation of a microtubule-based “telocentrosome” that fosters microtubule motor-dependent telomere clustering.

      Masashi Yoshida, Satoshi Katsuyama, Kazuki Tateho, Hiroto Nakamura, Junpei Miyoshi, Tatsunori Ohba, Hirotada Matsuhara, Futaba Miki, Koei Okazaki, Tokuko Haraguchi, Osami Niwa, Yasushi Hiraoka, Ayumu Yamamoto
    • SecYEG activates GTPases to drive the completion of cotranslational protein targeting
      SecYEG activates GTPases to drive the completion of cotranslational protein targeting

      SecYEG drives conformational changes in the cotranslational targeting complex to activate it for GTP hydrolysis and the handover of the translating ribosome.

      David Akopian, Kush Dalal, Kuang Shen, Franck Duong, Shu-ou Shan
    • Robust polarity establishment occurs via an endocytosis-based cortical corralling mechanism
      Robust polarity establishment occurs via an endocytosis-based cortical corralling mechanism

      Cell polarity can be established via the spatial coordination of the opposing membrane trafficking activities of endocytosis and exocytosis.

      Mini Jose, Sylvain Tollis, Deepak Nair, Jean-Baptiste Sibarita, Derek McCusker
    • Clathrin and AP2 are required for PtdIns(4,5)P<sub>2</sub>-mediated formation of LRP6 signalosomes
      Clathrin and AP2 are required for PtdIns(4,5)P2-mediated formation of LRP6 signalosomes

      PtdIns(4,5)P2 promotes the assembly of LRP6 signalosomes at the cell surface via the recruitment of AP2 and clathrin.

      Ingyu Kim, Weijun Pan, Sara A. Jones, Youxin Zhang, Xiaowei Zhuang, Dianqing Wu
  • Articles

    • Condensin II initiates sister chromatid resolution during S phase
      Condensin II initiates sister chromatid resolution during S phase

      Condensin II initiates structural reorganization of duplicated chromosomes during S phase to prepare for their proper condensation and segregation in mitosis.

      Takao Ono, Daisuke Yamashita, Tatsuya Hirano
    • Rbfox3-regulated alternative splicing of Numb promotes neuronal differentiation during development
      Rbfox3-regulated alternative splicing of Numb promotes neuronal differentiation during development

      Rbfox3 is required to promote neuronal differentiation of postmitotic neurons through Numb alternative splicing.

      Kee K. Kim, Joseph Nam, Yoh-suke Mukouyama, Sachiyo Kawamoto
    • Conserved and divergent features of kinetochores and spindle microtubule ends from five species
      Conserved and divergent features of kinetochores and spindle microtubule ends from five species

      A comprehensive, cross-species electron tomography analysis of kinetochore–microtubule interfaces has provided insight into shared structural features and their likely functional consequences.

      J. Richard McIntosh, Eileen O’Toole, Kirill Zhudenkov, Mary Morphew, Cindi Schwartz, Fazly I. Ataullakhanov, Ekaterina L. Grishchuk
    • Rag GTPases mediate amino acid–dependent recruitment of TFEB and MITF to lysosomes
      Rag GTPases mediate amino acid–dependent recruitment of TFEB and MITF to lysosomes

      Active Rag GTPases are required for recruitment of TFEB to lysosomes and its phosphorylation by mTORC1, inhibiting its function under nutrient-rich conditions.

      Jose A. Martina, Rosa Puertollano
    • Grb2 controls phosphorylation of FGFR2 by inhibiting receptor kinase and Shp2 phosphatase activity
      Grb2 controls phosphorylation of FGFR2 by inhibiting receptor kinase and Shp2 phosphatase activity

      Grb2 inhibits the kinase activity of FGFR2 and the phosphatase activity of Shp2 to maintain homeostasis of receptor phosphorylation in the nonstimulated state.

      Zamal Ahmed, Chi-Chuan Lin, Kin M. Suen, Fernando A. Melo, James A Levitt, Klaus Suhling, John E. Ladbury
    • The microtubule affinity regulating kinase MARK4 promotes axoneme extension during early ciliogenesis
      The microtubule affinity regulating kinase MARK4 promotes axoneme extension during early ciliogenesis

      A functional screen identified MARK4 as a positive regulator of axonemal extension and ciliogenesis via its interaction with the mother centriolar protein ODF2.

      Stefanie Kuhns, Kerstin N. Schmidt, Jürgen Reymann, Daniel F. Gilbert, Annett Neuner, Birgit Hub, Ricardo Carvalho, Philipp Wiedemann, Hanswalter Zentgraf, Holger Erfle, Ursula Klingmüller, Michael Boutros, Gislene Pereira
    • Obscurin is required for ankyrinB-dependent dystrophin localization and sarcolemma integrity
      Obscurin is required for ankyrinB-dependent dystrophin localization and sarcolemma integrity

      Obscurin contributes to the organization of subsarcolemma microtubules, localization of dystrophin at costameres, and maintenance of sarcolemmal integrity in skeletal muscle fibers.

      Davide Randazzo, Emiliana Giacomello, Stefania Lorenzini, Daniela Rossi, Enrico Pierantozzi, Bert Blaauw, Carlo Reggiani, Stephan Lange, Angela K. Peter, Ju Chen, Vincenzo Sorrentino
    • Canonical Wnt signaling inhibits osteoclastogenesis independent of osteoprotegerin
      Canonical Wnt signaling inhibits osteoclastogenesis independent of osteoprotegerin

      Canonical Wnt signaling through Fzd8 and β-catenin negatively regulates osteoclast differentiation and reduces bone resorption independent of osteoprotegerin.

      Joachim Albers, Johannes Keller, Anke Baranowsky, Frank Timo Beil, Philip Catala-Lehnen, Jochen Schulze, Michael Amling, Thorsten Schinke
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The Journal of Cell Biology: 200 (4)

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