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July 2014 | Volume 206, No. 2

News

  • In This Issue

    • Exploring the LINC to nuclear envelope spacing
      Exploring the LINC to nuclear envelope spacing
      Ben Short
    • GAAC pathway limits autophagy to a light snack
      GAAC pathway limits autophagy to a light snack
      Ben Short
    • Deubiquitination helps Rad18 grow more tolerant
      Deubiquitination helps Rad18 grow more tolerant
      Ben Short
  • In Focus

    • Lipids help epithelia stand tall
      Lipids help epithelia stand tall

      Palmitoylation and phosphoinositides target ankyrin-G/βII-spectrin network to lateral membranes.

      Ben Short
  • People & Ideas

    • Gohta Goshima: Questing for answers on the mitotic spindle
      Gohta Goshima: Questing for answers on the mitotic spindle

      Goshima studies spindle assembly and microtubule dynamics.

      Caitlin Sedwick

Review

  • Review

    • Targeting potassium channels in cancer
      Targeting potassium channels in cancer
      Xi Huang, Lily Yeh Jan

Research Articles

  • Reports

    • The SUN protein UNC-84 is required only in force-bearing cells to maintain nuclear envelope architecture
      The SUN protein UNC-84 is required only in force-bearing cells to maintain nuclear envelope architecture

      SUN-KASH bridges that connect the nucleoskeleton to the cytoskeleton are only required to maintain nuclear envelope spacing in cells subjected to increased mechanical forces, such as muscle cells.

      Natalie E. Cain, Erin C. Tapley, Kent L. McDonald, Benjamin M. Cain, Daniel A. Starr
    • The general amino acid control pathway regulates mTOR and autophagy during serum/glutamine starvation
      The general amino acid control pathway regulates mTOR and autophagy during serum/glutamine starvation

      To meet their metabolic needs, starved cells first activate autophagy, but activation in parallel of the general amino acid control pathway increases amino acid uptake, leading to reactivation of mTOR and down-regulation of autophagy.

      Rui Chen, Yilong Zou, Dongxue Mao, Daxiao Sun, Guanguang Gao, Jingwen Shi, Xiaoqing Liu, Chen Zhu, Mingyu Yang, Wanlu Ye, Qianqian Hao, Ruiqiang Li, Li Yu
  • Articles

    • DNA damage-specific deubiquitination regulates Rad18 functions to suppress mutagenesis
      DNA damage-specific deubiquitination regulates Rad18 functions to suppress mutagenesis

      Deubiquitination of Rad18 drives its localization to sites of DNA damage and formation of the Rad18–SHPRH complexes necessary for error-free lesion bypass.

      Michelle K. Zeman, Jia-Ren Lin, Raimundo Freire, Karlene A. Cimprich
    • Klar ensures thermal robustness of <em>oskar</em> localization by restraining RNP motility
      Klar ensures thermal robustness of oskar localization by restraining RNP motility

      When temperature fluctuation threatens the fidelity of Drosophila oogenesis, Klar restrains posterior-ward translocation of oskar mRNA, thereby adapting the rate of oskar delivery to the capacity of the anchoring machinery.

      Imre Gaspar, Yanxun V. Yu, Sean L. Cotton, Dae-Hwan Kim, Anne Ephrussi, Michael A. Welte
    • AGO3 Slicer activity regulates mitochondria–nuage localization of Armitage and piRNA amplification
      AGO3 Slicer activity regulates mitochondria–nuage localization of Armitage and piRNA amplification

      The endonuclease AGO3 and mitochondria-associated protein Zucchini together control the dynamic subcellular localization of Armitage between mitochondria and germline granules to regulate secondary piRNA amplification.

      Haidong Huang, Yujing Li, Keith E. Szulwach, Guoqiang Zhang, Peng Jin, Dahua Chen
    • Direct kinetochore–spindle pole connections are not required for chromosome segregation
      Direct kinetochore–spindle pole connections are not required for chromosome segregation

      In the absence of continuous K-fiber attachment between each kinetochore and the spindle pole, one or more additional mechanisms dependent on dynein-mediated kinetochore transport exist to ensure proper chromosome segregation during mitosis.

      Vitali Sikirzhytski, Valentin Magidson, Jonathan B. Steinman, Jie He, Maël Le Berre, Irina Tikhonenko, Jeffrey G. Ault, Bruce F. McEwen, James K. Chen, Haixin Sui, Matthieu Piel, Tarun M. Kapoor, Alexey Khodjakov
    • Force on spindle microtubule minus ends moves chromosomes
      Force on spindle microtubule minus ends moves chromosomes

      After the loss of continuous spindle microtubule attachment to the spindle pole, a previously undescribed mechanism of chromosome transport, powered by dynein pulling on minus ends of severed microtubules, repairs spindle architecture and integrity.

      Mary Williard Elting, Christina L. Hueschen, Dylan B. Udy, Sophie Dumont
    • Excess centrosomes disrupt endothelial cell migration via centrosome scattering
      Excess centrosomes disrupt endothelial cell migration via centrosome scattering

      Centrosome–microtubule interactions during interphase are important for centrosome clustering and cell polarity.

      Erich J. Kushner, Luke S. Ferro, Jie-Yu Liu, Jessica R. Durrant, Stephen L. Rogers, Andrew C. Dudley, Victoria L. Bautch
    • Ankyrin-G palmitoylation and βII-spectrin binding to phosphoinositide lipids drive lateral membrane assembly
      Ankyrin-G palmitoylation and βII-spectrin binding to phosphoinositide lipids drive lateral membrane assembly

      Palmitoylation of ankyrin-G and interaction of βII-spectrin with phosphoinositides are necessary for ankyrin-G–βII-spectrin localization in membrane subdomains during lateral membrane assembly in columnar epithelial cells.

      Meng He, Khadar M. Abdi, Vann Bennett
    • <em>Drosophila</em> Sirt2/mammalian SIRT3 deacetylates ATP synthase β and regulates complex V activity
      Drosophila Sirt2/mammalian SIRT3 deacetylates ATP synthase β and regulates complex V activity

      Sirtuin-mediated deacetylation of the catalytic subunit of mitochondrial complex V increases complex activity.

      Motiur Rahman, Niraj K. Nirala, Alka Singh, Lihua Julie Zhu, Kaori Taguchi, Takeshi Bamba, Eiichiro Fukusaki, Leslie M. Shaw, David G. Lambright, Jairaj K. Acharya, Usha R. Acharya
    • A RAB5/RAB4 recycling circuitry induces a proteolytic invasive program and promotes tumor dissemination
      A RAB5/RAB4 recycling circuitry induces a proteolytic invasive program and promotes tumor dissemination

      RAB5A and RAB4 promote breast tumor cell dissemination by controlling the trafficking of proteins necessary for localized invadosome formation.

      Emanuela Frittoli, Andrea Palamidessi, Paola Marighetti, Stefano Confalonieri, Fabrizio Bianchi, Chiara Malinverno, Giovanni Mazzarol, Giuseppe Viale, Ines Martin-Padura, Massimilliano Garré, Dario Parazzoli, Valentina Mattei, Salvatore Cortellino, Giovanni Bertalot, Pier Paolo Di Fiore, Giorgio Scita
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The Journal of Cell Biology: 206 (2)

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