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August 2015 | Volume 210, No. 5

News

  • In This Issue

    • Starving tumors eat metabolic enzyme
      Starving tumors eat metabolic enzyme
      Mitch Leslie
    • Phospholipid prunes actin branches
      Phospholipid prunes actin branches
      Mitch Leslie
    • Hsc70’s trip to the tip
      Hsc70’s trip to the tip
      Mitch Leslie
  • In Focus

    • Mast cells get all touchy-feely
      Mast cells get all touchy-feely

      “Allergy” cells embrace dendritic cells to transfer antigens.

      Mitch Leslie
  • People & Ideas

    • Nick Lane: Unearthing the first cellular innovations
      Nick Lane: Unearthing the first cellular innovations

      Lane’s unorthodox career stalks the origins of complex eukaryotic life.

      Kendall Powell
  • Feature

    • Jump-starting life? Fundamental aspects of synthetic biology
      Jump-starting life? Fundamental aspects of synthetic biology
      Petra Schwille

Review

  • Comment

    • Concentrating on the mitotic spindle
      Concentrating on the mitotic spindle
      Paul S. Maddox, Anne-Marie Ladouceur

Research Articles

  • Reports

    • An organelle-exclusion envelope assists mitosis and underlies distinct molecular crowding in the spindle region
      An organelle-exclusion envelope assists mitosis and underlies distinct molecular crowding in the spindle region

      A microtubule-independent membranous “spindle envelope” confines spindle assembly and accounts for faithful chromosome segregation.

      Nina Schweizer, Nisha Pawar, Matthias Weiss, Helder Maiato
    • Degradation of HK2 by chaperone-mediated autophagy promotes metabolic catastrophe and cell death
      Degradation of HK2 by chaperone-mediated autophagy promotes metabolic catastrophe and cell death

      Metabolic stress caused by perturbation of receptor tyrosine kinase FLT3 sensitizes cancer cells to autophagy inhibition and leads to excessive activation of chaperone-mediated autophagy, which triggers metabolic catastrophe in cancer cells through the degradation of HK2.

      Hong-guang Xia, Ayaz Najafov, Jiefei Geng, Lorena Galan-Acosta, Xuemei Han, Yuan Guo, Bing Shan, Yaoyang Zhang, Erik Norberg, Tao Zhang, Lifeng Pan, Junli Liu, Jonathan L. Coloff, Dimitry Ofengeim, Hong Zhu, Kejia Wu, Yu Cai, John R. Yates, Zhengjiang Zhu, Junying Yuan, Helin Vakifahmetoglu-Norberg
    • APC is required for muscle stem cell proliferation and skeletal muscle tissue repair
      APC is required for muscle stem cell proliferation and skeletal muscle tissue repair

      In muscle stem cells, APC dampens canonical Wnt signaling to allow cell cycle progression.

      Alice Parisi, Floriane Lacour, Lorenzo Giordani, Sabine Colnot, Pascal Maire, Fabien Le Grand
    • Usp16 regulates kinetochore localization of Plk1 to promote proper chromosome alignment in mitosis
      Usp16 regulates kinetochore localization of Plk1 to promote proper chromosome alignment in mitosis

      CDK1 and Plk1 sequentially phosphorylate and activate Usp16, which in turn deubiquitinates Plk1 to maintain the kinase’s kinetochore localization and promote proper chromosome alignment in mitosis.

      Xiaolong Zhuo, Xiao Guo, Xiaoyan Zhang, Guihua Jing, Yao Wang, Qiang Chen, Qing Jiang, Junjun Liu, Chuanmao Zhang
  • Articles

    • TTBK2 with EB1/3 regulates microtubule dynamics in migrating cells through KIF2A phosphorylation
      TTBK2 with EB1/3 regulates microtubule dynamics in migrating cells through KIF2A phosphorylation

      The microtubule (MT) plus end–tracking protein TTBK2 phosphorylates kinesin-13 family MT depolymerase KIF2A and removes it from MTs, thereby antagonizing KIF2A-induced depolymerization at MT plus ends during cell migration.

      Takashi Watanabe, Mai Kakeno, Toshinori Matsui, Ikuko Sugiyama, Nariko Arimura, Kenji Matsuzawa, Aya Shirahige, Fumiyoshi Ishidate, Tomoki Nishioka, Shinichiro Taya, Mikio Hoshino, Kozo Kaibuchi
    • PI(3,5)P<sub>2</sub> controls endosomal branched actin dynamics by regulating cortactin–actin interactions
      PI(3,5)P2 controls endosomal branched actin dynamics by regulating cortactin–actin interactions

      The late endosomal lipid PI(3,5)P2 binds to cortactin through the filamentous actin (F-actin) binding domain of cortactin, leading to removal of cortactin from endosomal actin networks and inhibition of cortactin-mediated branched actin nucleation and stabilization.

      Nan Hyung Hong, Aidong Qi, Alissa M. Weaver
    • Protein kinase D promotes plasticity-induced F-actin stabilization in dendritic spines and regulates memory formation
      Protein kinase D promotes plasticity-induced F-actin stabilization in dendritic spines and regulates memory formation

      PKD regulates the stabilization of the F-actin network within dendritic spines upon chemically induced plasticity changes and is needed for proper hippocampal LTP and spatial memory formation.

      Norbert Bencsik, Zsófia Szíber, Hanna Liliom, Krisztián Tárnok, Sándor Borbély, Márton Gulyás, Anikó Rátkai, Attila Szűcs, Diána Hazai-Novák, Kornelia Ellwanger, Bence Rácz, Klaus Pfizenmaier, Angelika Hausser, Katalin Schlett
    • Annexin A2–dependent actin bundling promotes secretory granule docking to the plasma membrane and exocytosis
      Annexin A2–dependent actin bundling promotes secretory granule docking to the plasma membrane and exocytosis

      Annexin A2 and the actin cytoskeleton are essential partners in providing lipid platforms for granule recruitment and fusion during exocytosis.

      Marion Gabel, Franck Delavoie, Valérie Demais, Cathy Royer, Yannick Bailly, Nicolas Vitale, Marie-France Bader, Sylvette Chasserot-Golaz
    • Polarized E-cadherin endocytosis directs actomyosin remodeling during embryonic wound repair
      Polarized E-cadherin endocytosis directs actomyosin remodeling during embryonic wound repair

      Clathrin, dynamin, and ARF6 accumulate around wounds in Drosophila embryos in a calcium- and actomyosin-dependent manner and drive polarized E-cadherin endocytosis, which is necessary for actomyosin remodeling during wound repair.

      Miranda V. Hunter, Donghoon M. Lee, Tony J.C. Harris, Rodrigo Fernandez-Gonzalez
    • Hsc70 chaperone activity underlies Trio GEF function in axon growth and guidance induced by netrin-1
      Hsc70 chaperone activity underlies Trio GEF function in axon growth and guidance induced by netrin-1

      Hsc70 chaperone activity is required for Rac1 activation by Trio and this function underlies netrin-1/DCC-dependent axon outgrowth and guidance.

      Jonathan DeGeer, Andrew Kaplan, Pierre Mattar, Morgane Morabito, Ursula Stochaj, Timothy E. Kennedy, Anne Debant, Michel Cayouette, Alyson E. Fournier, Nathalie Lamarche-Vane
    • The caveolin–cavin system plays a conserved and critical role in mechanoprotection of skeletal muscle
      The caveolin–cavin system plays a conserved and critical role in mechanoprotection of skeletal muscle

      The caveolar membrane microdomain plays an integral role in stabilizing the muscle fiber surface in mice and zebrafish.

      Harriet P. Lo, Susan J. Nixon, Thomas E. Hall, Belinda S. Cowling, Charles Ferguson, Garry P. Morgan, Nicole L. Schieber, Manuel A. Fernandez-Rojo, Michele Bastiani, Matthias Floetenmeyer, Nick Martel, Jocelyn Laporte, Paul F. Pilch, Robert G. Parton
    • Mast cells and dendritic cells form synapses that facilitate antigen transfer for T cell activation
      Mast cells and dendritic cells form synapses that facilitate antigen transfer for T cell activation

      Mast cells (MCs) and dendritic cells (DCs) form synapses that are dependent on MC activation and integrin engagement, and these direct interactions stimulate changes in the secretion profile of select cytokines and facilitate transfer of endosomal contents from activated MCs to DCs.

      Amanda Carroll-Portillo, Judy L. Cannon, Joost te Riet, Anna Holmes, Yuko Kawakami, Toshiaki Kawakami, Alessandra Cambi, Diane S. Lidke
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The Journal of Cell Biology: 210 (5)

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