January 2016 | Volume 212, No. 2
In This Issue
People & Ideas
- Loss of OMA1 delays neurodegeneration by preventing stress-induced OPA1 processing in mitochondria
Loss of OMA1 in a mouse model of neurodegeneration stabilizes fusion-active L-OPA1, which supports neuronal survival by preventing apoptosis, independent of its effects on cristae morphogenesis.
- Posttranslational marks control architectural and functional plasticity of the nuclear pore complex basket
Ubiquitin modifications of the nuclear pore complex (NPC) control the architectural plasticity of the nuclear basket, contributing to its tethering to the core NPC, with consequences on the cellular response to DNA damage and telomere recombination.
- Negative regulation of phosphatidylinositol 3-phosphate levels in early-to-late endosome conversion
C. elegans SORF-1 and SORF-2 and their mammalian homologs WDR91 and WDR81 maintain appropriate PtdIns3P levels in early-to-late endosome conversion by forming a complex with the Beclin1 subunit of the PI3K complex.
- P-cadherin promotes collective cell migration via a Cdc42-mediated increase in mechanical forces
P-cadherin induces polarization and collective cell migration through an increase in the strength and anisotropy of mechanical forces, which is mediated by the P-cadherin/β-PIX/Cdc42 axis.
- Myosin-dependent remodeling of adherens junctions protects junctions from Snail-dependent disassembly
During Drosophila gastrulation, subapical junctions are repositioned toward the apical surface and, as cortical tension increases, are strengthened in a myosin II–dependent manner, which may reflect a mechanosensitive response of junctional complexes to the tension generated by the activation of myosin.
- Class III myosins shape the auditory hair bundles by limiting microvilli and stereocilia growth
Analysis of mice deficient for myosin IIIa and myosin IIIb shows that class III myosins limit the elongation of stereocilia and of subsequently regressing microvilli, thus contributing to the early hair bundle shaping.
- Inducible fluorescent speckle microscopy
Generation of high-contrast and high-signal fluorescent 3D speckles allows fluorescent speckle microscopy to be performed in readily available libraries of cell lines and primary tissues for the measurement of microtubule turnover and sliding.