February 2016 | Volume 212, No. 5
In This Issue
People & Ideas
- ALIX and ESCRT-I/II function as parallel ESCRT-III recruiters in cytokinetic abscission
Cytokinetic abscission, the final stage of cell division, is mediated by the ESCRT machinery. Here, Christ et al. dissect the regulation of ESCRT-III recruitment and abscission timing and identify an intersection with abscission checkpoint signaling in cells with chromatin bridges.
- Assembly, molecular organization, and membrane-binding properties of development-specific septins
Analysis of the contribution of meiotic septins Spr3 and Spr28 to overall septin complex architecture at the ultrastructural level provides insights into how alternative subunits endow septin complexes with unique properties.
- Drp1-dependent mitochondrial fission via MiD49/51 is essential for apoptotic cristae remodeling
Drp1-dependent mitochondrial fission through MiD49 and MiD51, but not through Mff, is essential for cristae remodeling to facilitate cytochrome c release during the early phase of intrinsic apoptosis.
- Elevated p62/SQSTM1 determines the fate of autophagy-deficient neural stem cells by increasing superoxide
Comparison of autophagy inhibition by deletion of Atg5, Atg16L1, Atg7, or Fip200 reveals a critical role for increased p62 in determining the fate of autophagy-deficient neural stem cells by controlling intracellular superoxide.
- Synergistic action of nectins and cadherins generates the mosaic cellular pattern of the olfactory epithelium
Cellular rearrangements between olfactory cells and supporting cells, driven by the different expression and distribution of nectins and cadherins, are required for mosaic cellular patterning in the olfactory epithelium.
- Fat2 acts through the WAVE regulatory complex to drive collective cell migration during tissue rotation
The atypical cadherin Fat2 binds the WAVE regulatory complex (WRC) and acts with receptor tyrosine phosphatase Dlar through the WRC to control collective cell migration during Drosophila oogenesis.