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October 2016 | Volume 215, No. 2

News

  • In Focus

    • How morphine tips the synaptic balance
      How morphine tips the synaptic balance

      Study identifies pathway that alters hippocampal synapses after exposure to morphine.

      Ben Short
  • People & Ideas

    • Katja Röper: Deciphering tissue origami
      Katja Röper: Deciphering tissue origami

      Katja Röper investigates how cytoskeletal behaviour controls tissue morphogenesis.

      Marie Anne O’Donnell

Commentary

  • Spotlight

    • Slip slidin’ away of mitosis with CRL2<sup>Zyg11</sup>
      Slip slidin’ away of mitosis with CRL2Zyg11

      Michael Brandeis discusses the identification of the E3 ligase responsible for cyclin B1 degradation and mitotic slippage in cancer cells.

      Michael Brandeis
    • Radial migration: Retinal neurons hold on for the ride
      Radial migration: Retinal neurons hold on for the ride

      Kay discusses the recent characterization of the different modes of retinal ganglion cell migration and their cell biological basis.

      Jeremy N. Kay

Research Articles

  • Articles

    • The ubiquitin ligase CRL2<sup>ZYG11</sup> targets cyclin B1 for degradation in a conserved pathway that facilitates mitotic slippage
      The ubiquitin ligase CRL2ZYG11 targets cyclin B1 for degradation in a conserved pathway that facilitates mitotic slippage

      Cells arrested in mitosis by inactivation of the APC/C complex sometimes manage to exit mitosis in a process called mitotic slippage, which helps cancer cells circumvent chemotherapy drugs. Balachandran et al. show that mitotic slippage occurs as a result of targeting of cyclin B1 for degradation by the ligase CRL2ZYG11.

      Riju S. Balachandran, Cassandra S. Heighington, Natalia G. Starostina, James W. Anderson, David L. Owen, Srividya Vasudevan, Edward T. Kipreos
    • The lysosomal membrane protein SCAV-3 maintains lysosome integrity and adult longevity
      The lysosomal membrane protein SCAV-3 maintains lysosome integrity and adult longevity

      The mechanisms and determinants preserving lysosomal membrane stability are unclear. Here, Li et al. show that the lysosomal membrane protein SCAV-3, the Caenorhabditis elegans homologue of human LIMP-2, is a key regulator of lysosome integrity and normal adult lifespan.

      Yuan Li, Baohui Chen, Wei Zou, Xin Wang, Yanwei Wu, Dongfeng Zhao, Yanan Sun, Yubing Liu, Lianwan Chen, Long Miao, Chonglin Yang, Xiaochen Wang
    • The mitochondrial protein CHCHD2 primes the differentiation potential of human induced pluripotent stem cells to neuroectodermal lineages
      The mitochondrial protein CHCHD2 primes the differentiation potential of human induced pluripotent stem cells to neuroectodermal lineages

      Zhu et al. show that CHCHD2, a mitochondrial protein, primes the differentiation potential of human induced pluripotent stem cells (hiPSCs) to neuroectodermal lineages through binding and sequestering SMAD4 to the mitochondria and suppressing the activity of the TGFβ signaling pathway. CHCHD2 expression could be a useful tool to assay hiPSC differentiation potential.

      Lili Zhu, Aurora Gomez-Duran, Gabriele Saretzki, Shibo Jin, Katarzyna Tilgner, Dario Melguizo-Sanchis, Georgios Anyfantis, Jumana Al-Aama, Ludovic Vallier, Patrick Chinnery, Majlinda Lako, Lyle Armstrong
    • Kinesin-1 controls mast cell degranulation and anaphylaxis through PI3K-dependent recruitment to the granular Slp3/Rab27b complex
      Kinesin-1 controls mast cell degranulation and anaphylaxis through PI3K-dependent recruitment to the granular Slp3/Rab27b complex

      Activation of mast cells through IgE and antigen triggers the release of secretory granules that contain factors responsible for anaphylactic responses. Munoz et al. show that kinesin-1 regulates mast cell degranulation through PI3K-dependent formation of a kinesin-1/Slp3/Rab27b complex.

      Isabelle Munoz, Luca Danelli, Julien Claver, Nicolas Goudin, Mathieu Kurowska, Iris Karina Madera-Salcedo, Jian-Dong Huang, Alain Fischer, Claudia González-Espinosa, Geneviéve de Saint Basile, Ulrich Blank, Gaël Ménasché
    • Unidirectional Eph/ephrin signaling creates a cortical actomyosin differential to drive cell segregation
      Unidirectional Eph/ephrin signaling creates a cortical actomyosin differential to drive cell segregation

      Eph/ephrins drive cell segregation and boundary formation. O’Neill et al. discover that segregation is driven by unidirectional kinase-dependent EphB signaling. Unidirectional signaling generates a cortical actin differential between ephrin-B1– and EphB2-expressing cells and requires ROCK activity for cell segregation.

      Audrey K. O’Neill, Abigail A. Kindberg, Terren K. Niethamer, Andrew R. Larson, Hsin-Yi Henry Ho, Michael E. Greenberg, Jeffrey O. Bush
    • Nuclear calcium is required for human T cell activation
      Nuclear calcium is required for human T cell activation

      Monaco et al. demonstrate that calcium signals in activated human T cells consist of a cytoplasmic and a nuclear component, which are both required for the immune response. Blockade of nuclear calcium signaling inhibits T cell activation and induces an anergy-like state.

      Sara Monaco, Beate Jahraus, Yvonne Samstag, Hilmar Bading
    • Regulation of morphine-induced synaptic alterations: Role of oxidative stress, ER stress, and autophagy
      Regulation of morphine-induced synaptic alterations: Role of oxidative stress, ER stress, and autophagy

      Cai et al. demonstrate that morphine exposure dysregulates synaptic balance in the hippocampus. This effect involves a novel pathway involving ROS, ER stress, and autophagy and can be rescued by PDGF.

      Yu Cai, Lu Yang, Guoku Hu, Xufeng Chen, Fang Niu, Li Yuan, Han Liu, Huangui Xiong, Jyothi Arikkath, Shilpa Buch
    • Independent modes of ganglion cell translocation ensure correct lamination of the zebrafish retina
      Independent modes of ganglion cell translocation ensure correct lamination of the zebrafish retina

      Icha et al. show that retinal ganglion cells (RGCs) can move by two different modes across the embryonic zebrafish retina and that correct RGC translocation is crucial for neuronal lamination and retinal development.

      Jaroslav Icha, Christiane Kunath, Mauricio Rocha-Martins, Caren Norden
  • Tools

    • Subdiffractional tracking of internalized molecules reveals heterogeneous motion states of synaptic vesicles
      Subdiffractional tracking of internalized molecules reveals heterogeneous motion states of synaptic vesicles

      Joensuu et al. describe a tool for subdiffractional tracking of internalized molecules. They reveal that synaptic vesicles exhibit stochastic switching between heterogeneous diffusive and transport states in live hippocampal nerve terminals.

      Merja Joensuu, Pranesh Padmanabhan, Nela Durisic, Adekunle T.D. Bademosi, Elizabeth Cooper-Williams, Isabel C. Morrow, Callista B. Harper, WooRam Jung, Robert G. Parton, Geoffrey J. Goodhill, Andreas Papadopulos, Frédéric A. Meunier
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The Journal of Cell Biology: 215 (2)

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