Fasting produces an increased mobilization of lipid from adipose tissue to the liver and a decreased hepatic lipogenesis, but the administration of glucose stimulates lipid synthesis by the liver. After fasting of C3H mice numerous electron-opaque bodies and large lipid droplets were present in the liver. In the liver of untreated controls only a few small electron-opaque bodies and an occasional fat droplet were observed. After glucose injection the number of electron-opaque bodies in the liver was no greater than that observed in livers of saline-injected controls. In the livers of all groups these bodies were located intracellularly within cytoplasmic vesicles; those in extracellular locations were not membrane bounded and were located at indented and thickened hepatocyte plasma membranes or within the space of Disse. In fasted liver the dense bodies were often associated with large fat droplets.
Article|
September 01 1967
ELECTRON-OPAQUE BODIES AND FAT DROPLETS IN MOUSE LIVER AFTER FASTING OR GLUCOSE INJECTION
Nancy L. Trotter
Nancy L. Trotter
From the Department of Anatomy, the College of Physicians & Surgeons of Columbia University, New York 10032
Search for other works by this author on:
Nancy L. Trotter
From the Department of Anatomy, the College of Physicians & Surgeons of Columbia University, New York 10032
Received:
August 01 1966
Online ISSN: 1540-8140
Print ISSN: 0021-9525
Copyright © 1967 by The Rockefeller University Press
1967
J Cell Biol (1967) 34 (3): 703–711.
Article history
Received:
August 01 1966
Citation
Nancy L. Trotter; ELECTRON-OPAQUE BODIES AND FAT DROPLETS IN MOUSE LIVER AFTER FASTING OR GLUCOSE INJECTION . J Cell Biol 1 September 1967; 34 (3): 703–711. doi: https://doi.org/10.1083/jcb.34.3.703
Download citation file: