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jcb Home » 1969 Archive » 1 August » 42 (2): 392
Article

PARTICIPATION OF THE RETINAL PIGMENT EPITHELIUM IN THE ROD OUTER SEGMENT RENEWAL PROCESS

Richard W. Young, Dean Bok
Richard W. Young
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Dean Bok
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DOI: 10.1083/jcb.42.2.392 | Published August 1, 1969
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Abstract

The disposal phase of the retinal rod outer segment renewal process has been studied by radioautography in adult frogs injected with tritiated amino acids. Shortly after injection, newly formed radioactive protein is incorporated into disc membranes which are assembled at the base of the rod outer segment. During the following 2 months, these labeled discs are progressively displaced along the outer segment owing to the repeated formation of newer discs. When the labeled membranes reach the end of the outer segment, they are detached from it. They subsequently may be identified in inclusion bodies within the pigment epithelium by virtue of their content of radioactivity. These inclusions have been termed phagosomes. Disc membrane formation is a continuous process, but the detachment of groups of discs occurs intermittently. The detached outer segment fragments become deformed, compacted, undergo chemical changes, and are displaced within the pigment epithelium. Ultimately, the material contained in the phagosomes is eliminated from the cell. In this manner the pigment epithelium participates actively in the disposal phase of the rod outer segment renewal process.

Footnotes

    • Submitted: 16 January 1969
    • Revision received 10 March 1969
© 1969 Rockefeller University Press
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PARTICIPATION OF THE RETINAL PIGMENT EPITHELIUM IN THE ROD OUTER SEGMENT RENEWAL PROCESS
Richard W. Young, Dean Bok
The Journal of Cell Biology Aug 1969, 42 (2) 392-403; DOI: 10.1083/jcb.42.2.392

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The Journal of Cell Biology: 217 (4)

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April 2, 2018
Volume 217, No. 4

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