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Video 3
Cilengitide promotes a rapid/random mode of cell migration that is opposed by expression of dominant-negative RCP. Cells were transfected with GFP-RCP621E and allowed to grow to confluence. Confluent monolayers were wounded with a plastic pipette tip and the cells were allowed to migrate into the wound in presence of 1 ┬ÁM cilengitide. The cells were observed by time-lapse video microscopy and images were captured at four frames per hour over a period of 12 h, and the video was generated from these. The video plays at nine frames per second.