Supplement to Long astral microtubules uncouple mitotic spindles from the cytokinetic furrow
biosights: July 12, 2010
Long Asters Rock The Spindle
The Rockefeller University Press
Astral microtubules help position the cytokinetic furrow by confining actomyosin contractility to the cell equator. Rankin and Wordeman reveal that if astral microtubules grow too long, they expand membrane blebs at the mitotic cell poles that squeeze the mitotic spindle back and forth between the two daughter cells. This biosights episode presents the paper by Rankin and Wordeman from the July 12, 2010 issue of The Journal of Cell Biology, and includes an interview with senior author Linda Wordeman. Produced by Caitlin Sedwick and Ben Short.