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Cover picture: Expression patterns of two lacZ gene constructs containing the promoter and other regulatory regions of the gene for the L1 cell adhesion molecule. Whole mounts of transgenic embryos were analyzed at embryonic day 8.5, 9.5, 10.5, 11.5, and 12.5. (Top) Embryos carrying the native L1 gene construct show a pattern of β-galactosidase expression that is restricted to the nervous system. (Bottom) Embryos carrying a similar L1 gene construct in which the neural restrictive silencer element is deleted show an extensive extraneural expression in addition to the neural pattern. 9×. See related article in this issue by Kallunki et al., 1343–1354.
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