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Cover picture: Particles are translocated rapidly along flagellar microtubules by a process called intraflagellar transport (IFT). This image shows Chlamydomonas basal body and flagellar localization of a polypeptide found in the IFT particles. The punctate staining of the flagella closely resembles the distribution of moving IFT particles observed by differential interference contrast microscopy. The IFT particles are composed of large protein complexes containing at least 15 polypeptides. The anterograde movement of IFT particles to the distal tip of the flagellum is powered by FLA10 kinesin-II. A Chlamydomonas dynein light chain mutant is defective in the retrograde movement of IFT particles, suggesting that dynein is the motor for retrograde IFT. Homologues of IFT proteins and motors are required for assembly of the sensory neurons in Caenorhabditis elegans, indicating that IFT is important in a wide range of cilia-based structures. See related articles in this issue by Cole et al., 993–1008 and Pazour et al., 979–992.
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