About the Cover
Cover picture: The immunofluorescence picture shows the keratin filament network in a newborn transgenic mouse skin keratinocyte in primary culture. The animal from which the cell is derived has been engineered to express the type I keratin 16 as a replacement for keratin 14, whose genomic locus has been ablated. The abnormally thick filament bundles seen in the cell are primarily made of K16 and the type II keratin 5. The electron micrograph shows negatively stained keratin filaments reconstituted from purified keratins 5 and 16 proteins, and again here there is extensive bundling. See related article in this issue by Paladini and Coulombe, 1185-1201.
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