About the Cover
Cover picture: Laser scanning confocal fluorescence image showing the organization of the Golgi membranes during various stages of the cell cycle. Normal rat kidney cells (courtesy of Dr. Lippincott-Schwartz) expressing galactosyl transferase-YFP (shown green) were costained with the DNA-specific stain propidium iodide (shown blue) and antitubulin antibody (shown red). In the nondividing cells the Golgi membranes are found in the perinuclear area. As the cells enter mitosis the Golgi membranes, DNA and the microtubules undergo a dramatic change in spatial organization. In metaphase, the Golgi membranes are found as discrete fragments spread throughout the cytoplasm. This conversion of the pericentriolarly organized Golgi membrane stacks into large discrete units is mediated by the mitogen-activated protein kinase kinase 1 (MEK1). In early anaphase, the Golgi membranes appear predominantly diffusely dispersed. Whether this reorganization corresponds to Golgi membranes in the form of vesicles or their relocation to the ER is still under debate. In late anaphase and telophase, the Golgi membranes again appear as discrete fragments. These fragments ultimately coalesce into the pericentriolar region of each daughter cell. See related article in this issue by Colanzi et al., 331-339.
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