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Cover picture: Apical membrane localization of the adenomatous polyposis coli (APC) tumor suppressor protein in mouse colonic epithelium. Double immunofluorescence staining of APC (red) and beta-catenin (green) in tissue sections of normal mouse colon. In addition to the apical plasma membrane of the epithelial cells, there is APC staining in the nonepithelial cells of the lamina propria and throughout the submucosa. See related article in this issue by Reinacher-Schick et al., 491-502.
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