To see an article, click its [Full Text] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.
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In This Issue:

In Focus:

Myosins pull together—separately

Mitch Leslie Study suggests that asynchronous molecular motors can integrate their actions. J. Cell Biol. 2009 187: 3. Published Sep 28 2009, 10.1083/jcb.1871if. [Full Text] [PDF (577K)]  

People & Ideas:

Irina Conboy: Making the old feel young again

Kendall Powell Conboy has found her niche in chasing down what ails aged, decrepit muscle stem cells. J. Cell Biol. 2009 187: 4-5. Published Oct 5 2009, 10.1083/jcb.1871pi. [Full Text] [PDF (602K)]  

R e s e a r c h    A r t i c l e s

Reports:

DNA replication times the cell cycle and contributes to the mid-blastula transition in Drosophila embryos

Mark L. McCleland, Antony W. Shermoen, and Patrick H. O'Farrell Deletion of S phase disrupts mitotic timing in maternally regulated cycles, but it doesn't alter the cell cycle once zygotic transcription has begun. J. Cell Biol. 2009 187: 7-14. Published Sep 28 2009, 10.1083/jcb.200906191. [Abstract] [Full Text] [PDF (3202K)] [PDF+supp data (4995K)] [Supplemental Material] [Related biosights video]   

Tim–Tipin dysfunction creates an indispensible reliance on the ATR–Chk1 pathway for continued DNA synthesis

Kevin D. Smith, Michael A. Fu, and Eric J. Brown Increased amounts of single-stranded DNA accumulate at replication forks when Tim–Tipin isn't around, activating an ATR-mediated DNA damage response necessary for DNA replication to proceed. J. Cell Biol. 2009 187: 15-23. Published Oct 5 2009, 10.1083/jcb.200905006. [Abstract] [Full Text] [PDF (5176K)] [PDF+supp data (7333K)] [Supplemental Material]   

INTS3 controls the hSSB1-mediated DNA damage response

Jeffrey R. Skaar, Derek J. Richard, Anita Saraf, Alfredo Toschi, Emma Bolderson, Laurence Florens, Michael P. Washburn, Kum Kum Khanna, and Michele Pagano MISE is identified as a component of the Integrator complex required for DNA repair. J. Cell Biol. 2009 187: 25-32. Published Sep 28 2009, 10.1083/jcb.200907026. [Abstract] [Full Text] [PDF (3766K)] [PDF+supp data (6075K)] [Supplemental Material]   

An eIF4E-binding protein regulates katanin protein levels in C. elegans embryos

Wei Li, Leah R. DeBella, Tugba Guven-Ozkan, Rueyling Lin, and Lesilee S. Rose SPN2 represses katanin translation to prevent mitotic defects (independently of ubiquitin-mediated katanin degradation). J. Cell Biol. 2009 187: 33-42. Published Sep 28 2009, 10.1083/jcb.200903003. [Abstract] [Full Text] [PDF (4432K)] [PDF+supp data (5300K)] [Supplemental Material]   

Relative contributions of chromatin and kinetochores to mitotic spindle assembly

Christopher B. O'Connell, Jadranka Loncarek, Petr Kaláb, and Alexey Khodjakov It's the kinetochores, not the DNA, that initiate spindle assembly. J. Cell Biol. 2009 187: 43-51. Published Oct 5 2009, 10.1083/jcb.200903076. [Abstract] [Full Text] [PDF (5973K)] [PDF+supp data (9695K)] [Supplemental Material]   

Coupled myosin VI motors facilitate unidirectional movement on an F-actin network

Sivaraj Sivaramakrishnan and James A. Spudich A combination of experimentation and modeling reveal that multiple myosin VI molecules coordinately transport cargo over the actin filament network. J. Cell Biol. 2009 187: 53-60. Published Sep 28 2009, 10.1083/jcb.200906133. [Abstract] [Full Text] [PDF (3255K)] [PDF+supp data (3999K)] [Supplemental Material]   

Glyburide inhibits the Cryopyrin/Nalp3 inflammasome

Mohamed Lamkanfi, James L. Mueller, Alberto C. Vitari, Shahram Misaghi, Anna Fedorova, Kurt Deshayes, Wyne P. Lee, Hal M. Hoffman, and Vishva M. Dixit Glyburide, a sulfonylurea drug commonly used to treat type 2 diabetes, shuts down IL-1β secretion by preventing Cyropyrin activation. J. Cell Biol. 2009 187: 61-70. Published Oct 5 2009, 10.1083/jcb.200903124. [Abstract] [Full Text] [PDF (3077K)] [PDF+supp data (4482K)] [Supplemental Material]   

Autophagy promotes synapse development in Drosophila

Wei Shen and Barry Ganetzky The ubiquitin–proteosome and autophagy pathways work together to regulate synaptic growth and plasticity in response to environmental conditions. J. Cell Biol. 2009 187: 71-79. Published Sep 28 2009, 10.1083/jcb.200907109. [Abstract] [Full Text] [PDF (3469K)] [PDF+supp data (3908K)] [Supplemental Material]   

Intraflagellar transport particle size scales inversely with flagellar length: revisiting the balance-point length control model

Benjamin D. Engel, William B. Ludington, and Wallace F. Marshall Chlamydomonas reinhardtii IFT particle trains, important for flagella maintenance and assembly, are observed to decrease in size as a function of cilia length. J. Cell Biol. 2009 187: 81-89. Published Oct 5 2009, 10.1083/jcb.200812084. [Abstract] [Full Text] [PDF (2522K)] [PDF+supp data (4113K)] [Supplemental Material]   

Epidermal progenitors give rise to Merkel cells during embryonic development and adult homeostasis

Alexandra Van Keymeulen, Guilhem Mascre, Khalil Kass Youseff, Itamar Harel, Cindy Michaux, Natalie De Geest, Caroline Szpalski, Younes Achouri, Wilhelm Bloch, Bassem A. Hassan, and Cédric Blanpain Lineage-tracing experiments show that the origin of specialized mechanosensory Merkel cells in the skin is epidermal progenitors, not the neural crest. J. Cell Biol. 2009 187: 91-100. Published Sep 28 2009, 10.1083/jcb.200907080. [Abstract] [Full Text] [PDF (3446K)] [PDF+supp data (4766K)] [Supplemental Material]   

Articles:

Molecular mechanisms that enhance synapse stability despite persistent disruption of the spectrin/ankyrin/microtubule cytoskeleton

Catherine M. Massaro, Jan Pielage, and Graeme W. Davis Neuromuscular junctions crippled by a disrupted microtubule cytoskeleton are rescued by stress-induced activation of MAPK-JNK-Fos signaling. J. Cell Biol. 2009 187: 101-117. Published Oct 5 2009, 10.1083/jcb.200903166. [Abstract] [Full Text] [PDF (4065K)] [PDF+supp data (5045K)] [Supplemental Material]   

Cdc42 antagonizes Rho1 activity at adherens junctions to limit epithelial cell apical tension

Stephen J. Warner and Gregory D. Longmore Rho promotes actomyosin contractility during epithelial cell remodeling, but Cdc42 keeps the epithelium in shape by limiting RhoA activity. J. Cell Biol. 2009 187: 119-133. Published Oct 5 2009, 10.1083/jcb.200906047. [Abstract] [Full Text] [PDF (8026K)] [PDF+supp data (16926K)] [Supplemental Material] [Related biobytes podcast]   

Electron-tomographic analysis of intraflagellar transport particle trains in situ

Gaia Pigino, Stefan Geimer, Salvatore Lanzavecchia, Eugenio Paccagnini, Francesca Cantele, Dennis R. Diener, Joel L. Rosenbaum, and Pietro Lupetti Ultrastructural study of Chlamydomonas cilia shows that anterograde IFT particles form trains that are long and narrow, while retrograde IFT form short, compact particle trains. J. Cell Biol. 2009 187: 135-148. Published Oct 5 2009, 10.1083/jcb.200905103. [Abstract] [Full Text] [PDF (5119K)] [PDF+supp data (7918K)] [Supplemental Material]   

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.