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P o d c a s t s   free access

October 19, 2009 Keratins regulate protein biosynthesis; Mast cell signaling to lymph nodes; Cdc42 and epithelial cell shape

N e w s   free access

In This Issue:

In Focus:

The different ties that bind

Ben Short Two homologues of the cohesin protein Scc3 have specialized roles in chromatid cohesion. J. Cell Biol. 2009 187: 151. Published Oct 12 2009, 10.1083/jcb.1872if. [Full Text] [PDF (503K)]  

People & Ideas:

Senthil Muthuswamy: A new road map for cancer

Caitlin Sedwick Senthil Muthuswamy uses 3D cell culture to explore the influence of cell polarity on oncogenic transformation. J. Cell Biol. 2009 187: 152-153. Published Oct 19 2009, 10.1083/jcb.1872pi. [Full Text] [PDF (648K)]  

Editorial:

JCB meeting: Cell Biology of Disease

Tom Misteli
J. Cell Biol. 2009 187: 155-156. Published Oct 19 2009, 10.1083/jcb.200909171. [Full Text] [PDF (1173K)]  

R e v i e w s   free access

Comments:

Keratins and protein synthesis: the plot thickens

Juliane C. Kellner and Pierre A. Coulombe
J. Cell Biol. 2009 187: 157-159. Published Oct 19 2009, 10.1083/jcb.200909134. [Abstract] [Full Text] [PDF (1149K)]  

It takes two to tango to the melanosome

Aparna Lakkaraju, Jose Maria Carvajal-Gonzalez, and Enrique Rodriguez-Boulan
J. Cell Biol. 2009 187: 161-163. Published Oct 19 2009, 10.1083/jcb.200909100. [Abstract] [Full Text] [PDF (1087K)]  

R e s e a r c h    A r t i c l e s

Reports:

Differential regulation of telomere and centromere cohesion by the Scc3 homologues SA1 and SA2, respectively, in human cells

Silvia Canudas and Susan Smith In vertebrates, two Scc3 homologues control sister chromatid cohesion of distinct chromosomal regions. J. Cell Biol. 2009 187: 165-173. Published Oct 12 2009, 10.1083/jcb.200903096. [Abstract] [Full Text] [PDF (3006K)] [PDF+supp data (3517K)] [Supplemental Material]   

Keratins regulate protein biosynthesis through localization of GLUT1 and -3 upstream of AMP kinase and Raptor

Preethi Vijayaraj, Cornelia Kröger, Ursula Reuter, Reinhard Windoffer, Rudolf E. Leube, and Thomas M. Magin Removal of the entire keratin family of intermediate filament proteins from embryonic epithelia has surprising implications for mTOR signaling. J. Cell Biol. 2009 187: 175-184. Published Oct 19 2009, 10.1083/jcb.200906094. [Abstract] [Full Text] [PDF (7962K)] [PDF+supp data (10951K)] [Supplemental Material] [Related biobytes podcast]   

Articles:

Cohesin SMC1β protects telomeres in meiocytes

Caroline Adelfalk, Johannes Janschek, Ekaterina Revenkova, Cornelia Blei, Bodo Liebe, Eva Göb, Manfred Alsheimer, Ricardo Benavente, Esther de Boer, Ivana Novak, Christer Höög, Harry Scherthan, and Rolf Jessberger Telomeres fail to attach to the nuclear envelope and lose structural integrity in cells lacking SMC1β. J. Cell Biol. 2009 187: 185-199. Published Oct 19 2009, 10.1083/jcb.200808016. [Abstract] [Full Text] [PDF (3837K)] [PDF+supp data (5331K)] [Supplemental Material]   

Ubiquilin and p97/VCP bind erasin, forming a complex involved in ERAD

Precious J. Lim, Rebecca Danner, Jing Liang, Howard Doong, Christine Harman, Deepa Srinivasan, Cara Rothenberg, Hongmin Wang, Yihong Ye, Shengyun Fang, and Mervyn J. Monteiro Loss of ubiquilin or erasin activates ER stress, increases accumulation of polyubiquitinated proteins, and shortens lifespan in worms. J. Cell Biol. 2009 187: 201-217. Published Oct 12 2009, 10.1083/jcb.200903024. [Abstract] [Full Text] [PDF (5467K)] [PDF+supp data (7198K)] [Supplemental Material]   

Temporal regulation of Drosophila IAP1 determines caspase functions in sensory organ development

Akiko Koto, Erina Kuranaga, and Masayuki Miura Caspase activation is regulated by the turnover of E3 ubiquitin ligase, DIAP1, and depends on cell type and maturity. J. Cell Biol. 2009 187: 219-231. Published Oct 12 2009, 10.1083/jcb.200905110. [Abstract] [Full Text] [PDF (3126K)] [PDF+supp data (4915K)] [Supplemental Material]   

Pex3 peroxisome biogenesis proteins function in peroxisome inheritance as class V myosin receptors

Jinlan Chang, Fred D. Mast, Andrei Fagarasanu, Dorian A. Rachubinski, Gary A. Eitzen, Joel B. Dacks, and Richard A. Rachubinski Pex3 links peroxisome formation and inheritance. By binding to class V myosin, biogenesis protein Pex3 also directs the organelles into daughter cells. J. Cell Biol. 2009 187: 233-246. Published Oct 12 2009, 10.1083/jcb.200902117. [Abstract] [Full Text] [PDF (7612K)] [PDF+supp data (8179K)] [Supplemental Material]   

AP-1 and KIF13A coordinate endosomal sorting and positioning during melanosome biogenesis

Cédric Delevoye, Ilse Hurbain, Danièle Tenza, Jean-Baptiste Sibarita, Stéphanie Uzan-Gafsou, Hiroshi Ohno, Willie J.C. Geerts, Arie J. Verkleij, Jean Salamero, Michael S. Marks, and Graça Raposo The clathrin adaptor protein AP-1 and the motor KIF13A work together to deliver cargo into maturing melanosomes. J. Cell Biol. 2009 187: 247-264. Published Oct 19 2009, 10.1083/jcb.200907122. [Abstract] [Full Text] [PDF (7543K)] [PDF+supp data (12560K)] [Supplemental Material] [biosights video]   

Spred2 interaction with the late endosomal protein NBR1 down-regulates fibroblast growth factor receptor signaling

Faraz K. Mardakheh, Mona Yekezare, Laura M. Machesky, and John K. Heath Neighbor of BRCA1 (NBR1) suppresses growth factor responses by redirecting activated receptors to lysosomes for degradation. J. Cell Biol. 2009 187: 265-277. Published Oct 12 2009, 10.1083/jcb.200905118. [Abstract] [Full Text] [PDF (3223K)] [PDF+supp data (4201K)] [Supplemental Material]   

PIKfyve regulates Ca_V1.2 degradation and prevents excitotoxic cell death

Fuminori Tsuruta, Eric M. Green, Matthieu Rousset, and Ricardo E. Dolmetsch Neuronal Ca levels are regulated by glutamate receptor activation, which recruits PIKfyve to voltage-gated Ca channels, prompting their degradation. J. Cell Biol. 2009 187: 279-294. Published Oct 19 2009, 10.1083/jcb.200903028. [Abstract] [Full Text] [PDF (7658K)] [PDF+supp data (11252K)] [Supplemental Material]   

Postsynaptic regulation of synaptic plasticity by synaptotagmin 4 requires both C2 domains

Cynthia F. Barber, Ramon A. Jorquera, Jan E. Melom, and J. Troy Littleton Analogous to synaptotagmin 1, a calcium-sensitive regulator of presynaptic vesicle fusion, synaptotagmin 4 needs both of its calcium-binding sites to regulate synaptic plasticity via postsynaptic retrograde signaling. J. Cell Biol. 2009 187: 295-310. Published Oct 12 2009, 10.1083/jcb.200903098. [Abstract] [Full Text] [PDF (11059K)] [PDF+supp data (12337K)] [Supplemental Material]   

O f    I n t e r e s t

From J. Exp. Med.:

Phosphoinositide-dependent kinase 1 controls migration and malignant transformation but not cell growth and proliferation in PTEN-null lymphocytes

David K. Finlay, Linda V. Sinclair, Carmen Feijoo, Caryll M. Waugh, Thijs J. Hagenbeek, Hergen Spits, and Doreen A. Cantrell [Full Text]  

Loss of matrix metalloproteinase 2 in platelets reduces arterial thrombosis in vivo

Stefania Momi, Emanuela Falcinelli, Silvia Giannini, Loredana Ruggeri, Luca Cecchetti, Teresa Corazzi, Claude Libert, and Paolo Gresele [Full Text]  

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.