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[Index by Author] 

P o d c a s t s   free access

November 2, 2009 Melanosomes and endosomes dance together

N e w s   free access

In This Issue:

-TuRC gives microtubules pause for thought [Full Text]  

Raf-1 sheds then spreads its inhibitions [Full Text]  

Chemosensitivity depends on the dependency [Full Text]  

In Focus:

Not the average view of adipogenesis

Ben Short Study on cell heterogeneity offers a surprising twist to adipocyte differentiation. J. Cell Biol. 2009 187: 315. Published Oct 26 2009, 10.1083/jcb.1873if. [Full Text] [PDF (526K)]  

People & Ideas:

Irving Weissman: Working for regenerative medicine

Nicole LeBrasseur A force behind both the science and politics of stem cell biology, Weissman now strives to translate his successes to the clinic. J. Cell Biol. 2009 187: 316-317. Published Nov 2 2009, 10.1083/jcb.1873pi. [Full Text] [PDF (705K)]  

R e v i e w s   free access

Review:

The ubiquitin landscape at DNA double-strand breaks

Troy E. Messick and Roger A. Greenberg
J. Cell Biol. 2009 187: 319-326. Published Nov 2 2009, 10.1083/jcb.200908074. [Abstract] [Full Text] [PDF (1452K)]  

R e s e a r c h    A r t i c l e s

Reports:

-Tubulin ring complexes regulate microtubule plus end dynamics

Anaïs Bouissou, Christel Vérollet, Aureliana Sousa, Paula Sampaio, Michel Wright, Claudio E. Sunkel, Andreas Merdes, and Brigitte Raynaud-Messina Independently of their nucleation activity, -tubulin ring complex proteins localize along microtubules, limiting catastrophe events during interphase. J. Cell Biol. 2009 187: 327-334. Published Oct 26 2009, 10.1083/jcb.200905060. [Abstract] [Full Text] [PDF (4126K)] [PDF+supp data (5120K)] [Supplemental Material]   

From autoinhibition to inhibition in trans: the Raf-1 regulatory domain inhibits Rok- kinase activity

Théodora Niault, Izabela Sobczak, Katrin Meissl, Gregory Weitsman, Daniela Piazzolla, Gabriele Maurer, Florian Kern, Karin Ehrenreiter, Matthias Hamerl, Ismail Moarefi, Thomas Leung, Oliviero Carugo, Tony Ng, and Manuela Baccarini The mechanism by which Raf-1 antagonizes Rok- to promote migration and tumorigenesis is revealed. J. Cell Biol. 2009 187: 335-342. Published Nov 2 2009, 10.1083/jcb.200906178. [Abstract] [Full Text] [PDF (4693K)] [PDF+supp data (5742K)] [Supplemental Material]   

Enhancement of Notch receptor maturation and signaling sensitivity by Cripto-1

Kazuhide Watanabe, Tadahiro Nagaoka, Joseph M. Lee, Caterina Bianco, Monica Gonzales, Nadia P. Castro, Maria Cristina Rangel, Kei Sakamoto, Youping Sun, Robert Callahan, and David S. Salomon Cripto-1 associates with Notch1 in the endoplasmic reticulum and Golgi to enhance Notch1 localization to lipid rafts and its maturation. J. Cell Biol. 2009 187: 343-353. Published Nov 2 2009, 10.1083/jcb.200905105. [Abstract] [Full Text] [PDF (5682K)] [PDF+supp data (7402K)] [Supplemental Material] [Related biobytes podcast]   

Ana3 is a conserved protein required for the structural integrity of centrioles and basal bodies

Naomi R. Stevens, Jeroen Dobbelaere, Alan Wainman, Fanni Gergely, and Jordan W. Raff Centriolar protein Ana3 is essential for basal body formation, not centriole duplication, as previously thought. J. Cell Biol. 2009 187: 355-363. Published Oct 26 2009, 10.1083/jcb.200905031. [Abstract] [Full Text] [PDF (4440K)] [PDF+supp data (9245K)] [Supplemental Material]   

Lateral transport of Smoothened from the plasma membrane to the membrane of the cilium

Ljiljana Milenkovic, Matthew P. Scott, and Rajat Rohatgi A distinct pathway for ligand-stimulated lateral trafficking of the hedgehog protein Smoothened into cilia is described. J. Cell Biol. 2009 187: 365-374. Published Oct 26 2009, 10.1083/jcb.200907126. [Abstract] [Full Text] [PDF (8631K)] [PDF+supp data (14870K)] [Supplemental Material]   

Heterogeneity in the physiological states and pharmacological responses of differentiating 3T3-L1 preadipocytes

Lit-Hsin Loo, Hai-Jui Lin, Dinesh K. Singh, Kathleen M. Lyons, Steven J. Altschuler, and Lani F. Wu A systems biology–based analysis shows that differentiating adipocytes look very different at the single-cell level and form distinct cellular subpopulations. J. Cell Biol. 2009 187: 375-384. Published Oct 26 2009, 10.1083/jcb.200904140. [Abstract] [Full Text] [PDF (4376K)] [PDF+supp data (5832K)] [Supplemental Material]   

Articles:

Mammalian Rif1 contributes to replication stress survival and homology-directed repair

Sara B.C. Buonomo, Yipin Wu, David Ferguson, and Titia de Lange Multifunctional protein Rif1 accumulates at stalled replication forks to facilitate DNA repair during S phase. J. Cell Biol. 2009 187: 385-398. Published Nov 2 2009, 10.1083/jcb.200902039. [Abstract] [Full Text] [PDF (3523K)] [PDF+supp data (5742K)] [Supplemental Material]   

Ase1/Prc1-dependent spindle elongation corrects merotely during anaphase in fission yeast

Thibault Courtheoux, Guillaume Gay, Yannick Gachet, and Sylvie Tournier The tug of war that ensues when a kinetochore binds microtubules from both spindle poles is resolved by Ase1/Prc1. J. Cell Biol. 2009 187: 399-412. Published Nov 2 2009, 10.1083/jcb.200902093. [Abstract] [Full Text] [PDF (4256K)] [PDF+supp data (6798K)] [Supplemental Material]   

Membrane proteins Bqt3 and -4 anchor telomeres to the nuclear envelope to ensure chromosomal bouquet formation

Yuji Chikashige, Miho Yamane, Kasumi Okamasa, Chihiro Tsutsumi, Tomoko Kojidani, Mamiko Sato, Tokuko Haraguchi, and Yasushi Hiraoka A screen identifies two more bouquet proteins required for meiotic telomere clustering: Bqt4 anchors the telomeres, whereas Bqt3 protects Bqt4 from degradation. J. Cell Biol. 2009 187: 413-427. Published Nov 2 2009, 10.1083/jcb.200902122. [Abstract] [Full Text] [PDF (3698K)] [PDF+supp data (4195K)] [Supplemental Material]   

MCL-1–dependent leukemia cells are more sensitive to chemotherapy than BCL-2–dependent counterparts

Joslyn K. Brunelle, Jeremy Ryan, Derek Yecies, Joseph T. Opferman, and Anthony Letai Cancer-expressed anti-apoptotic protein BCL-2 is stable, whereas MCL-1 undergoes proteasome-dependent degradation in response to chemotherapeutic agents. J. Cell Biol. 2009 187: 429-442. Published Oct 26 2009, 10.1083/jcb.200904049. [Abstract] [Full Text] [PDF (3536K)] [PDF+supp data (4457K)] [Supplemental Material]   

O f    I n t e r e s t

From J. Exp. Med.:

Runx proteins regulate Foxp3 expression

Ludovica Bruno, Luca Mazzarella, Maarten Hoogenkamp, Arnulf Hertweck, Bradley S. Cobb, Stephan Sauer, Suzana Hadjur, Marion Leleu, Yoshinori Naoe, Janice C. Telfer, Constanze Bonifer, Ichiro Taniuchi, Amanda G. Fisher, and Matthias Merkenschlager [Full Text]  

Prospective identification, isolation, and systemic transplantation of multipotent mesenchymal stem cells in murine bone marrow

Satoru Morikawa, Yo Mabuchi, Yoshiaki Kubota, Yasuo Nagai, Kunimichi Niibe, Emi Hiratsu, Sadafumi Suzuki, Chikako Miyauchi-Hara, Narihito Nagoshi, Takehiko Sunabori, Shigeto Shimmura, Atsushi Miyawaki, Taneaki Nakagawa, Toshio Suda, Hideyuki Okano, and Yumi Matsuzaki [Full Text]  

Spermatozoa capture HIV-1 through heparan sulfate and efficiently transmit the virus to dendritic cells

Ana Ceballos, Federico Remes Lenicov, Juan Sabatté, Christian Rodríguez Rodrígues, Mercedes Cabrini, Carolina Jancic, Silvina Raiden, Mónica Donaldson, Rodolfo Agustín Pasqualini, Jr., Clara Marin-Briggiler, Mónica Vazquez-Levin, Francisco Capani, Sebastián Amigorena, and Jorge Geffner [Full Text]  

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.