Table 1. Rescue of NGF deprivation–induced neuronal death and degeneration by tyrosine kinase inhibitors
Target kinaseInhibitorSubjective survival rate
Day2Day3Day4
GSK3βCT99021+++++/−
CHIR98014 isomer++++/−
TWS119+++
BCR, Abl, SrcPonatinib++++++
TrkAK-252a++++
Lestaurtinib+++++++
JNKSP-600125+++++
EGFR, HER2CI-1033+++++
Tyrphostin B44+++++++
MET, VEGFRSunitinib malate+++++++
Foretinib++++++++++++

Neonatal rat sympathetic neurons withdrawn from NGF for 6 h were cultured without NGF and with 1 µM of tyrosine kinase inhibitors for 2–4 d more. Survival and axonal integrity was subjectively estimated on each day. “++++” cultures with morphology comparable with those maintained in NGF; “−” cultures similar to NGF-withdrawn untreated cultures.