Table I.

Overexpression of Bub1 in MEFs induces progressive near-diploid aneuploidy

MEF genotype (n)Mitotic figures inspectedAneuploid figures (SD)Karyotypes with indicated chromosome numberMitotic figures with PMSCS (SD)
37383940414243
%%
WT (3)15011 (1)215133721 (1)
Bub1T85 (3)15021 (1)2191181558 (0)
WT (3)15011 (1)51338313 (1)
Bub1T264 (3)15025 (1)13221139212 (1)
  • Empty spaces mean that there were no karyotypes with the indicated chromosome number. Karyotyping was performed at passage 5.