Table II

Effect of β1-Inhibitory Antibody Induced Phenotype Reversion on Tumorigenicity In Vivo

Treatment descriptionTotal number of tumors per groupTumor size
Large tumors*Small tumors‡Mice with no tumors
Control
nontreated
T4-2 cells15/1614/161/161/16
Non-immune
rat IgG-treated
T4-2 cells14/1611/163/162/16
β1-integrin
function blocking
antibody-treated T4-2 cells 7/16 5/16§2/169/16§
  • *  tumors >5 <300 mm3.  

  •  tumors <5 mm3.  

  • §P < 0.005 by X2 test.