Table III

Testing Actin Inhibitors for Effects on Yeast Cells In Vivo

Halo diameter
DrugWild-type (ERG6)Δerg6S. pombe
mm
Latrunculin-A132428
Latrunculin-B102223
Mycalolide-B111913
Swinholide-A10
Jasplakinolide
Cytochalasin-B
  • Halo assays were used to determine whether the indicated drugs were able to inhibit growth in either wild-type S. cerevisiae cells or in S. cerevisiae cells in which the ERG6 gene was deleted to increase cell permeability. Results for wild-type S. pombe are also presented. The results presented here are the halo size (mm) obtained when 1 mM of each drug was tested.