Table I

DMBA-induced Carcinomas in ST3+/+ and ST3/− Mice

StrainsDMBA-induced mouse carcinomas*
No tumorBenign tumorsCarcinomasSize‡
ST3+/+  0/9 (0%)      1/9 (11%) 8/9 (89%)230 ± 276
ST3−/−3/14 (21%)5/14 (36%)6/14 (43%) 38 ± 49
  • *  Animals were killed at 35 weeks of age.  

  •  Mean of carcinoma volumes in mm3; the median size of ST3+/+ and ST3−/− carcinomas were 140 (range 16–729) and 16 (range 8–125), respectively. Benign tumors, ovarian hyperplasia and mammary cysts; carcinomas, ovarian and mammary gland carcinomas.