Table I

Number of Capillaries Proximal to and Distal from the Limbic Region of the Cornea of Mice Receiving mAb to VEGF by i.v. Injection or by Corneal Implant in the FGF-2–Containing Pellet

i.v. injectionPellet
ProximalDistalProximalDistal
vesselvesselvesselvessel
(n)*(%)(n)*(%)(n)*(%)(n)*(%)
PBS15.7 ± 1.1100.0    41 ± 3.1 97.2
n.i. IgG15.7 ± 1.1100.042.3 ± 1.5100.0 15.3 ± 1.0100.030.0 ± 1.3100.0
VEGF Ab13.8 ± 1.5 87.9‡25.2 ± 0.9 59.6§11.3 ± 0.9 73.8‡15.2 ± 0.9 50.7§
  • *  Mean of 12 eyes per group ± SEM.  

  • P < 0.01.  

  • §P < 0.01. Statistical analysis performed by analysis of variance.