Table III

Meiotic Progression in Oocytes from MLH1 Null Females and Controls

PrometaphaseMeta IAna/MII
ApolarBipolarOther*
+/−41 4
 4 h(91%)(9%)
−/−4526 1
(63%)(36%)(1%)
+/− 7  8 9
 6 h(29%)(33%)(38%)
−/− 740 7
(13%)(74%)(13%)
+/− 2 656 1
 8 h(3%)(9%)(86%)(2%)
−/− 338 4
(7%)(84%)(9%)
+/−3926
10 h(60%)(40%)
−/−27 3
(90%)(10%)
+/− 7‡32
12 h(18%)(82%)
−/− 342 5
(6%)(84%)(10%)
+/−
18 h
−/− 711 3
(33%)(52%)(14%)
  • *  Includes cells with collapsed spindles, spindles with grossly unequal poles, and tripolar spindles.  

  •  A proportion of control oocytes arrest at MI; this is a reflection of oocyte immaturity (Eppig et al., 1994).