Table 1

List of Shared Expression Changes of Genes in Dystrophin Deficiency and α-SGD

Average-fold changes
Accession no.Gene nameDystrophindeficiencyα-Sarcoglycandeficiency
Cell surface and extracellular matrix
S77094Nicotinic acetylcholine receptor α subunit 11917
HG2994-HT4850Elastin, alt. splice 21312
Z74616Prepro-α2(I) collagen117
U16306Chondroitin sulfate proteoglycan versican88
X53331Matrix Gla protein74
X52022Type VI collagen α3 chain75
HG3044-HT3742Fibronectin, alt. splice 166
M55998α-1 Collagen type I65
X15880Collagen VI α-1 COOH-terminal globular domain57
X02761Fibronectin (FN precursor) 143
Z74615Prepro-α1(I) collagen33
L02950μ-Crystallin −22−9
Intracellular signaling and cell–cell communication
M38591S100 calcium-binding protein A1056
M62403Insulin-like growth factor–binding protein 4 (IGFBP4)54
D13666Osteoblast-specific factor 2 (OSF-2os)47
M80563S100 calcium-binding protein A445
HG3543-HT3739Insulin-like growth factor 233
U09578MAPKAP kinase (3pK)−9−4
U50360Calcium, calmodulin-dependent protein kinase II γ−9 −12
L21993Adenyl cyclase−6−3
U07225P2U nucleotide receptor−5−6
Immune response
M22430Phospholipase A2, group IIA4221
X573511-8D gene from interferon-inducible gene family3730
K02765Complement component C3, α and β subunits2211
X83703Cytokine-inducible nuclear protein816
M14058Complement C1r54
J04080Complement component C1s53
M65292Factor H homologue53
Energy metabolism and mitochondria function
HG4747-HT5195NADH-ubiquinone oxidoreductase, 51 kD subunit−6−5
U65579Mitochondrial NADH dehydrogenase-ubiquinone Fe-S protein 8−5−4
M69177Monoamine oxidase B (MAOB)−5−7
J05073Phosphoglycerate mutase (PGAM-M)−4−2
X66114Solute carrer family 25,member 11−4 −13
M37400Glutamate oxaloacetate transaminase−4−4
X05409Mitochondrial aldehyde dehydrogenase I ALDH I−4−3
M32598Glycogen phosphorylase (PYGM)−3−2
J04444Cytochrome c-1−3−3
X99728NADH-ubiquinone oxidoreductase flavoprotein 3−3−2
X73874Phosphorylase kinase,muscle,α1subunit−3−3
Z68204Succinyl CoA synthetase−3−4
M91463Glucose transporter (GLUT4)−3−4
S69232Electron transfer flavoprotein-ubiquinone oxidoreductase−3−4
L16842Cytochrome b of complex III−3−2
M22760Cytochrome c oxidase subunit Va (COX5A)−2−2
M22632Glutamate oxaloacetate transaminase−2−2
M15856Lipoprotein lipase−2−5
L24774Δ3, Δ2-CoA-isomerase−2−3
U49352Liver 2,4-dienoyl-CoA reductase 1−2−5
M22877Somatic cytochrome c (HCS)−2−2
U17886Succinate dehydrogenase complex subunit B −2−3
HG4334-HT4604Glycogenin −2−2
Z14244Cytochrome c oxidase subunit VIIb −2−2
Muscle structure and developmental genes
X13100Embryonic myosin heavy chain140124
Z38133Skeletal muscle perinatal myosin heavy chain (MYH8)5133
L05606Myosin-binding protein H3251
J00073α-cardiac actin79
L03785Regulatory myosin light chain (MYL5)55
U34301Nonmuscle myosin heavy chain IIB gene34
S81737α-1 Syntrophin −14−6
X06956 (probe set 1)α-Tubulin −11−7
HG2259-HT2348(probe set 2)α-Tubulin −8−6
L34355α-Sarcoglycan −3−5
Others and unknown
M14539Factor XIII subunit a2611
U51010 (probe set 1)Nicotinamide N-methyltransferase (NNMT)2217
U08021 (probe set 2)Nicotinamide N-methyltransferase (NNMT)2017
X96719Activation-induced C-type lectin (AICL)34
X82209Meningioma 1 −9−8
L11672Zinc finger protein 91 −5−6
HG3344-HT3521Ubiquitin-conjugating enzyme Ubch5 −4−5
U03056Tumor suppressor (LUCA-1) −4−5
M35252Transmembrane 4 superfamily member 3 −4−7
Y00339Carbonic anhydrase II −4−4
Z49878Guanidinoacetate N-methyltransferase −4−3
S83364Putative Rab5-interacting protein −4−3
U52960RNA polymerase II complex component SRB7 −3−4
U48707Protein phosphatase-1, regulatory subunit 8 −3−4
U05861Hepatic dihydrodiol dehydrogenase −3−3
AB002365KIAA0367 gene919
U61374Sushi-repeat–containing protein, X chromosome (SRPX)75
X67698Epididymal secretory protein (19.5 kD)53
U79253Clone 23893 −7−8
D80010KIAA0188 −6−6
D14660KIAA0104 −4−4