Table 3

Gene Expression Changes Confirmed by Immunofluorescence

Gene nameAccession no.-fold changeDMD-fold changeα-SGDNormal muscle localizationDystrophic muscle localization
Factor XIIIaM14539 +26 +11NoneCellular infiltrates
HLA-DR α heavy chainX00274+3+3Small amount endomysiumCellular infiltrates
Complement component 3K02765+22 +11NoneNecrotic muscle fibers
Secreted phospholipase A2M22430+42 +21NoneNecrotic muscle fibers
Thrombospondin-4Z19585+15 +23EndomysiumFocal increases
α-Cardiac actinJ00073+7+9NoneMajority of myofibers
Embryonic myosin heavy chainX13100+141 +124NoneRegenerating muscle fibers
Osteonectin/SPARCJ03040+5+4Rare, punctate staining endomysiumIncrease endomysium
VersicanU16306+8+8EndomysiumDiffuse increase endomysium