Table II.

Tissue distribution of [3H]glycerol-labeled HMDSCs after the injection ofmdxmice

HMDSCsHMDSCs + anti–L-selectinHMDSCs + F(ab) anti–L-selectinCell lysates
%/g%/g%/g%/g
Soleus muscle31 ± 0.058.72 ± 0.099.02 ± 0.11.24 ± 0.01
Pectoralis muscle22.45 ± 0.10a3.2 ± 0.373.3 ± 0.410.32 ± 0.04
Tibialis anterior muscle12.15 ± 0.013.5 ± 0.533.55 ± 0.650.7 ± 0.02
Triceps brachialis muscle5.31 ± 0.02a1.2 ± 0.011.23 ± 0.071.18 ± 0.01
Diaphragm33.05 ± 0.07a6.18 ± 0.026.18 ± 0.060.12 ± 0.21
Liver2.34 ± 2.101.2 ± 0.071.25 ± 0.096.23 ± 0.01
Kidney4.74 ± 0.371.8 ± 0.021.9 ± 0.041.44 ± 0.05
Lung1.5 ± 0.011.3 ± 0.151.1 ± 0.253.6 ± 0.02
Bone marrow1.8 ± 0.550.9 ± 0.320.7 ± 0.560.54 ± 0.1
Brain0.28 ± 0.20.2 ± 0.10.21 ± 0.151.18 ± 0.2
  • a P < 0.01 vs. HMDSCs + anti–L-selectin.

  • Radioactivity distribution in muscles and visceral organs of 2-mo-old mdx/mdx mice after the injection of [3H]glycerol-labeled HMDSCs with or without anti–L-selectin or the injection of cell lysates. Results are expressed as percentage of injected activity per gram of tissue (± SD) 2 h after i.v. injection.