Table I.

Effect of anti-α integrin subunit blocking antibodies on pulmonary arrest

Antibody specificityControlAntibodyInhibition
cells/mm2 ± SDcells/mm2 ± SD%
α16.00 ± 0.535.78 ± 0.654
α27.23 ± 0.296.10 ± 0.5215
α37.42 ± 1.074.93 ± 1.1434
α45.95 ± 0.645.02 ± 0.6616
α54.65 ± 1.735.03 ± 2.57  −8
α65.94 ± 1.876.20 ± 1.83  −5
αv6.20 ± 1.506.00 ± 2.073
  • HT1080-GFP cells were treated with the indicated blocking antibodies as described in the Materials and methods section. Each value is expressed as cells/mm2 ± SD. The anti-α3 subunit antibody used was P1B5. Similar results were obtained with ASC-1 (unpublished data). The comparison of means using t test was P = 0.03 for α2 integrin subunit blocking antibody and P = 0.05 for α3. The value for α4 was P = 0.15.