Table I.

Consensus names for human ArfGAPs, with additional information

SubfamilyNew
 consensus
 gene symbolsPrevious
 HGNC
 gene symbolsLiterature or database aliases/synonyms
Name #1Name #2Name #3Name #4KIAA#NCBI
 gene IDHuman gene
 locationAccession number (length)
ARFGAP1ARFGAP1ARFGAP1ArfGAP1Arf1GAPArf GAPMGC399245573820q13.33NM_018209; NP_060679 (406aa)
ARFGAP2ARFGAP2ARFGAP2ArfGAP2ZNF289/Zfp289FLJ14576FLJ260008436411p11.2-p11.12NM_032389; NP_115765 (521aa)
ARFGAP3ARFGAP3ArfGAP3ArfGAP12628622q13.2-q13.3NM_014570; NP_055385 (516aa)
ADAPADAP1CENTA1Centaurin
 (alpha1)PIPBPp42IP4GCS1L110337p22.3NM_006869; NP_006860 (374aa)
ADAP2CENTA2Centaurin
 (beta)Cent. Alpha2cent-bHSA2721955580317q11.2NM_018404; NP_060874 (381aa)
SMAPSMAP1SMAP1SMAP-1FLJ13159FLJ42245606826q13NM_001044305; NP_068759 (440aa)
SMAP2SMAP2SMAP1LRP1-228H13.3SMAP2647441p35.3-p34.1NM_022733; NP_073570 (429aa)
AGFGAGFG1HRBHRB1RIPHIV-1 Rev BPRAB32672q36.3NM_004504; NP_004495 (562aa)
AGFG2HRBLHRB2RAB-R/HRB1HIV-1 Rev BP-L32687q22.1NM_006076; NP_006067 (481aa)
GITGIT1GIT1Git1Cat1p95APP12896417p11.2NM_014030; NP_054749 (761aa)
GIT2GIT2Git2Cat2p95APP2p95PKLKIAA0148981512q24.1NM_057169; NP_476510 (759aa)
ASAPASAP1DDEF1AMAP1DEF1/DDEF1PAG2/SHAG1Cent. Beta4KIAA1249508078q24.1-q24.2NM_018482; NP_060952 (1129aa)
ASAP2DDEF2AMAP2PAP/DDEF2SHAG2/PAG3Cent. Beta3KIAA040088532p24NM_003887: NP_003878 (1006aa)
ASAP3DDEFL1DDEFL1UPLC1ACAP4Cent. Beta6556161p36.12NM_017707; NP_060177 (903aa)
ACAPACAP1CENTB1ACAP1Cent. Beta1KIAA0050974417p13.1NM_014716; NP_055531 (740aa)
ACAP2CENTB2ACAP2Cent. Beta2KIAA0041235273q29NM_012287; NP_036419 (778aa)
ACAP3CENTB5ACAP3Cent. Beta5KIAA17161169831p36NM_030649; NP_085152 (759aa)
AGAPAGAP1CENTG2AGAP1Cent. Gamma2GGAP1MGC71657KIAA10991169872q37NM_014914; NP_055729 (804aa)
AGAP2CENTG1AGAP2Cent. Gamma1GGAP2/PIKEFLJ16430KIAA016711698612q14.1NM_014770; NP_055585 (836aa);
 AAM97540 (1192aa)
AGAP3CENTG3AGAP3Cent. Gamma3MRIP1/CRAGFLJ161461169887q36.1NM_031946; NP_114152 (911aa)
AGAP4CTGLF1CTGLF1Centaurin gamma-like family 1MRIP211901610q11.21NM_133446; NP_597703 (663aa)
AGAP5CTGLF2CTGLF2Centaurin gamma-like family 272909210q22.2XM_001132588; XP_001132588 (686aa)
AGAP6CTGLF3CTGLF3Centaurin gamma-like family 341418910q11.23NM_001077665; NP_001071133 (686aa)
AGAP7CTGLF4CTGLF4Centaurin gamma-like family 465326810q11.23NM_001077685; NP_001071153 (663aa)
AGAP8CTGLF5CTGLF5Centaurin gamma-like family 572840410q11.23NM_001077686; NP_001071154 (663aa)
AGAP9CTGLF6CTGLF6Centaurin gamma-like family 6FLJ0031264251710q11.22NM_001077686 (663aa)
AGAP10CTGLF7CTGLF7Centaurin gamma-like family 772812710q11.22XR_015281 (655aa)
AGAP11KIAA1975Similar to MRIP2KIAA197511938510q23.2NP_597704 (550aa)
ARAPARAP1CENTD2ARAP1Cent. Delta2KIAA078211698511q13.4NM_001040118; NP_001035207 (1450aa)
ARAP2CENTD1ARAP2Cent. Delta1FLJ13675PARXKIAA05801169844p14NM_015230; NP_056045 (1704aa)
ARAP3CENTD3ARAP3Cent. Delta3FLJ21065DRAG1644115q31.3NM_022481; NP_071926 (1544aa)
  • List of consensus acronyms: ArfGAP = ADP-ribosylation factor GTPase activating proteins. ACAP = ArfGAP with coiled-coil, ankyrin repeat, and PH domains. ADAP = ArfGAP with dual PH domains. AGAP = ArfGAP with GTPase domain, ankyrin repeat, and PH domain. AGFG = ArfGAP with FG repeats. ARAP = ArfGAP with Rho GAP domain, ankyrin repeats and PH domain. ASAP = ArfGAP with SH3 domain, ankyrin repeat, and PH domain. GIT = G protein receptor kinase (GRK) interacting ArfGAP. SMAP = Small ArfGAP.

  • List of proposed discontinued acronyms: APP = ArfGAP putative, PIX1-interacting, paxillin binding protein. CAT = Cool-associated tyrosine phosphorylated protein. CTGLF = Centaurin gamma-like family. DEF = differentiation-enhancing factor. HRB = HIV Rev binding protein. PAG = paxillin associated Arf GAP. PAP = Pyk2 associated protein. PKL = paxillin-kinase linker. RAB = HIV Rev-associated binding protein. RIP = HIV Rev-interacting protein.