Table II.

Modal chromosome number and percentage of nonmodal cells in subclones generated from p53-null clones induced to persistently missegregate chromosomes for 27 generations

Cell lineMode (percent deviation)
Chr 2Chr 4Chr 7Chr 15
p53−/− G subclone 12 (3.3)a2 (5.3)2 (8.3)a2 (13.3)a
p53−/− H subclone 12 (3.3)2 (11.3)a2 (9.0)a2 (9.0)a
p53−/− H subclone 22 (14.3)a2 (16.7)a2 (18.0)a2 (14.7)a
p53−/− H subclone 32 (10.3)a2 (11.0)a2 (14.0)a2 (13.0)a
p53−/− H subclone 42 (5.0)2 (4.7)2 (4.7)2 (6.3)
p53−/− I subclone 12 (8.7)a2 (16.7)a2 (11.7)a2 (12.3)a
p53−/− J subclone 12 (4.7)2 (7.0)2 (9.7)a2 (8.3)a
p53−/− J subclone 24 (55.3)a2 (67.3)a4 (62.0)a2 (51.0)a
  • Chr, chromosome. 300 nuclei were counted per chromosome per subclone.

  • a Deviation from mode is statistically significant compared with p53+/+ controls in Table I (P < 0.05, χ2 test).