Table I.

Microarray analysis of Mesp1-GFP–expressing cells

CategoryUp-regulated genes
Transcription factors and chromatin remodelingHoxb1 (3.7), Foxc1* (3.5), Lmo1 (3.2), Foxc2* (3.0), Foxf1a (2.9), Pdlim4 (2.9), Isl1 (2.8), Hoxb2 (2.6), Mesp1 (2.6), Etv2 (2.4), Prrx2 (2.4), Tbx3 (2.4), Tbx6 (2.4), Snai1 (2.4), Lef1 (2.3), Msx2 (2.3), Smarcd3 (2.3), Mesp2 (2.2), Tbx2 (2.2), Evx1 (2.1), Hand1 (2.1), Meis2 (2.1), Prdm6 (2.1), Zcchc12 (2.1), Gata4 (2), Hand2 (2), Klhl6 (2), Msx1 (2), Six2 (2), Twist1* (2), Vax1 (2), Zeb2* (2), Bhlhe22 (1.9), Tbx20 (1.9), Zbtb7c (1.9), Ets1 (1.9), Hey2* (1.9), Smad6* (1.9), Zdhhc20* (1.9), Zcchc24* (1.9), Hmga2 (1.8), Hoxd1 (1.8), Pdlim5 (1.8), Tshz1 (1.8), Zfp516 (1.8), Hey1* (1.7), Smad1 (1.7), Cbx4 (1.7), Zfp423 (1.7), Foxh1 (1.6), Nfatc1* (1.6), Twist2* (1.6), Zeb1* (1.6)
Signaling pathways (other than receptors)
NotchDll1 (2.1), Dll3 (2.0), Hey2 (1.9), Hey1 (1.7)
WntWnt5a (3), Wnt2 (2.8), Wnt5b (2.1), Apcdd1 (1.8), Lef1 (1.8), Wnt3 (1.7)
FGFFgf3 (2.3), Fgf15 (1.7), Fgf10 (1.6)
TGF-bGdf10 (2.7), Tgfb2 (2.0), Lefty2 (1.9), Tgfbi (1.9), Tgfb1i1 (1.8), Vasn (1.7)
BmpBmper (2.4), Bmp4 (2.0), Bambi (1.7), Bmp6 (1.6), Smad6 (1.9), Smad1 (1.6)
OthersRasgrp3 (2.4), Rgs5 (2.7), Crabp1 (2.7), Htr1d (2.6), Adcyap1r1 (2.5), S1pr5 (2.4), Ptgds (2.3), Dusp9 (2.3), Cap2 (2.0), Dlc1 (1.9), Tnfsf13b (1.9), Adcy3 (1.9), Dok4 (1.9), Efna3 (1.8), Braf (1.7), Prkd1 (1.7), Alox15 (1.6), Pgr (1.6), Vegfc (1.6)
Membrane proteins and receptorsPcdh19 (3.1), Pdgfra (3.1), Ceacam10 (2.9), Cmklr1 (2.5), Gp1bb (2.5), Plac1 (2.5), Cacna1c (2.4), Odz4 (2.3), Nrp2 (2.3), Vldlr (2.3), Cdh4 (2.3), Pcdh18 (2.3), Adrb1 (2.2), Kdr (2.1), Rftn1 (2.1), Unc5c (2.1), Lhfp (2.0), Kcnd3 (2.0), Il13ra1 (2.0), Amhr2 (2.0), Cd160 (1.9), L1cam (1.9), Cxcr4 (1.9), Aplnr (1.9), Pcdh7 (1.9), Cxcr7 (1.9), Slc4a4 (1.9), Gpr177 (1.8), Itga8 (1.8), Prtg (1.8), Ednra (1.8), Kcnc1 (1.8), Cdh11 (1.7), Pcdh7 (1.7), Pdgfrb (1.7), Gfra2 (1.7), Trpc3 (1.7), Nrp1 (1.7), Cdh2 (1.7), Tmem88 (1.6), Il1rap (1.6), Lrp1 (1.6), Ms4a4d (1.6), Kctd15 (1.5)
Extracellular matrixCol6a1 (3.5), Col9a1 (2.6), Emid2 (2.4), Leprel1 (2.3), Fbln2 (2.2), Fbln7 (2.1), Lor (2.0), Col13a1 (2.0), Fn1 (1.9), Has2 (1.8), Vcan (1.6), Flnb (1.6), Mmp2 (1.6)
OthersSpp1 (5.8), Fabp4 (5.5), H60a (4.5), Ugt1a1 (4.0), Papss2 (3.8), Agpat9 (3.1), Ccdc109b (2.8), Phlda2 (2.6), Egln3 (2.5), Gna14 (2.5), Pcsk5 (2.4), Atp1a2 (2.4), Dock10 (2.3), Hs3st3b1 (2.3), Morc4 (2.3), Chst2 (2.3), Pmp22 (2.3), Adamts20 (2.2), St6galnac4 (2.2), Exoc3l (2.2), Fam123c (2.1), Myl7 (2.1), Prdm6 (2.1), Susd5 (2.1), Rbm24 (2.1), Siah2 (2.1), Mex3b (2.1), Chst7 (2.0), Nin (2.0), Actc1 (2.0), Kif26b (2.0), Ccnd2 (2.0), Itih5 (1.9), Man1c1 (1.9), Cbln1 (1.9), Mn1 (1.9), Sh3bp1 (1.9), Fam82a1 (1.8), Olfm1 (1.8), Serpinb9 (1.8), Cdkn1c (1.8), Phldb2 (1.8), Pmaip1 (1.8), Gas1 (1.8), Abtb2 (1.8), Adamts3 (1.7), Sgcb (1.7), Sbsn (1.7), Cyp2s1 (1.7), Adam19 (1.7), Brp44 (1.7), Cyp4f15 (1.7), Dclk1 (1.7), Slco3a1 (1.7), Bace2 (1.7), Car3 (1.7), Aard (1.6), Oaf (1.6), Zadh2 (1.6), As3mt (1.6), Grrp1 (1.6), Ablim1 (1.6), Fam122b (1.6), Gne (1.6), Ptprm (1.6), Rps6ka6 (1.6), Lmna (1.5), Man1a (1.5), Pwwp2b (1.5)
  • Fold changes are indicated in parentheses. Asterisks indicate genes found only in one of the two array replicates and confirmed by RT-PCR on different biological samples. Bold indicates genes found to be also up-regulated after Mesp1 overexpression.