Table 1.

Adaptor and accessory proteins involved in endocytosis

Mammalian proteinYeast homologueLipid-binding domainClathrin bindingExample of specific cargo uptakeReference for cargo uptake
AP2 (α, β2, μ2, σ2)AP2 (Apl3, Apl1, Apm4, Aps2)α-Core domain and μ2 C-terminal domainYesTransferrin receptorMotley et al., 2003
FCHo1/2Syp1F-BAR domainMid2 in yeastReider et al., 2009
AP180/CALMYap1801/2ANTHYesSNAREsMiller et al., 2011
Epsin1/2/3Ent1/2ENTHYesNotch ligandsMeloty-Kapella et al., 2012
Eps15Ede1/End3
Intersectin1/2Sla1/Pan1PH/C2Yes (for Sla1 in yeast)Ste2 in yeastHoward et al., 2002
HIP1/HIP1RSla2ANTHYes
Dab2PTBYesLDLRMaurer and Cooper, 2006
ARHPTBLDLRMaurer and Cooper, 2006
NumbPTBNotchSantolini et al., 2000
Stonin 2SynaptotagminDiril et al., 2006
β-Arrestin 1/2Arginine/lysine residuesYesGPCRsFerguson et al., 1996
  • ANTH, AP180 N-terminal homology; ENTH, epsin N-terminal homology; GPCR, G-protein–coupled receptor; LDLR, low-density lipoprotein receptor; PH, pleckstrin homology; PTB, phosphotyrosine binding. “–” indicates none known.