- Origins of antagonistic neurotrophin signaling
Keeler and Deppmann preview work from Foldi et al. that describes some of the cellular mechanisms governing the induction of survival and death decisions by Drosophila neurotrophic factors.
- A timeline for C. elegans ciliogenesis
Centrioles are known to be essential for cilia assembly. However, their contribution has not been clearly defined. Serwas et al. show that centrioles degenerate early in C. elegans ciliogenesis. Ciliary structures are not completely formed at this time, indicating that cilia maturation does not depend on intact centrioles.
- Smurf1 inhibits integrin activation
Integrin-mediated cellular functions require integrin activation by the proteins Kindlin-2 and Talin. Wei et al. show that the E3 ligase Smurf1 permits precise modulation of integrin-mediated adhesion by interacting with and promoting Kindlin-2 ubiquitination and degradation.
- Mature domain targeting
Secretory preproteins contain a mature domain fused to a signal peptide that targets the protein to the translocase, which mediates secretion. In this study, the authors show that the mature domains bear independent targeting signals (MTS) that consist of multiple, degenerate, interchangeable, linear or 3D hydrophobic stretches that are essential for proper secretion.
- The role of WDR81 in aggrephagy
Mutations in WDR81, a regulator of the endosomal–lysosomal pathway, are implicated in CAMRQ2 syndrome, which manifests as cerebellar ataxia, mental retardation, and quadrupedal locomotion in patients. In this study, Liu et al. uncover a distinct function of WDR81 in the clearance of ubiquitinated and aggregated proteins by autophagy.
- Role of myosin in neuroblast delamination
Sidor and Röper preview a study by Simões et al. that describes the function of myosin II in modulating apical constriction and cell contact loss during neuroblast ingression.
- Proteostasis regulation in multicellular organisms
This review by Morimoto and colleagues examines mechanisms by which protein homeostasis (proteostasis) is achieved in multicellular organisms and discusses the implications for health and disease.
- Plastin regulates cortical contractility
Ding et al. characterize the function of the F-actin bundling protein plastin in the Caenorhabditis elegans zygote. They demonstrate that plastin is important for optimal connectivity in the cortical actomyosin network that drives large-scale contractile processes such as polarization and cytokinesis.