- Molecular basis of receptor-mediated transcytosis
Transcytosis plays an important role in establishing cell polarity and in mediating transport of large cargo across epithelial barriers, but its molecular basis is unclear. Nelms et al. present a new dataset of genes involved in receptor-mediated transcytosis and show that the apical and basolateral recycling and transcytotic pathways are genetically separable.
- FKB-6 in meiotic chromosome pairing and synapsis
Dynein-mediated movement of microtubules is required for chromosome movement; its absence leads to aberrant segregation. Alleva et al. show that FKB-6, a cochaperone of Hsp-90, is required for proper chromosome movement through down-regulation of resting time between movements.
- A new family of eukaryotic kinetochore proteins
The kinetochore complex is conserved across many eukaryotes, but the protozoan lineage Kinetoplastida builds kinetochores from components without apparent homology to models. D’Archivio and Wickstead describe a new family of proteins with homology to outer kinetochore proteins Ndc80 and Nuf2 that defines the outer kinetochore of trypanosomes, suggesting that all eukaryotes have divergent versions of a universal kinetochore machine.
- Axonal autophagy promotes Wallerian degeneration
The pathophysiological function and induction mechanism of autophagy in neuronal axons have remained unclear. Wakatsuki et al. show that the GSK3B-mediated phosphorylation of MCL1 leads to its UPS-dependent degradation, which induces axonal autophagy and promotes axonal degeneration.
- Ferroptosis-like cell death in plants
Distéfano et al. show that an iron-dependent, oxidative cell death process with biochemical and morphological similarities to ferroptosis, as described in mammalian cells, has a physiological role in plants, regulating plant cell death in response to heat stress.
- PGAM1 inhibition impairs homologous recombination repair
Phosphoglycerate mutase 1 (PGAM1) regulates metabolism in cancer cells. Qu et al. show that PGAM1 maintains the intracellular dNTP pool, promotes the stability of CTBP-interacting protein, and is required for homologous recombination repair. PGAM1 inhibition sensitizes BRCA1/2-proficient breast cancer to PARP inhibitors.
- Schwann cell Merlin controls repair of the PNS
The regenerative capacity of Schwann cells in the PNS underlies functional repair after injury. In this study, Mindos et al. show a new function for the tumor suppressor Merlin and Hippo/YAP signaling in the generation of repair-competent Schwann cells after injury.